Effects of High Flow Nasal Cannula on Breathing and the Respiratory System Parameters

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04004247

Acronym

HaFo

Enrollment

Registered

2019-07-02

Start date

2019-06-01

Completion date

2024-02-06

Last updated

2024-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

High Flow Oxygenation, Electrical Impedance Tomography, Non invasive ventilation

Brief summary

The aim of this study is a detailed investigation of the effect of High Flow Nasal Oxygenation (HFNO) on respiratory system characteristics and ventilation parameters in healthy adult subjects and the subsequent use of measured data to answer the following questions: What level of positive end expiratory pressure (PEEP) causes a HFNO with different flow rates? Does HFNO work as pressure support or does it act more like a Continuous Positive Airway Pressure (CPAP) ventilation?

Detailed description

High Flow Oxygen through nasal cannula is widely used in the setting of hypoxemic respiratory failure of heterogenous etiology with very good patients compliance. However, the evidence of what level of PEEP or pressure support (if any) with different flow rates is weak. Our goal is to determine these effects and compare them with standard approach with non-invasive ventilation via full face mask.

Interventions

DEVICEHigh Flow Nasal generator (AirVO2)

High Flow Nasal Oxygenation

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Intervention model description

12 volunteers

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* healthy volunteers willing to participate

Exclusion criteria

* general contraindications for oesophageal catheter insertion: oesophageal varices, bleeding disorders (including anticoagulant medication), diverticulitis, oesophageal tumors, history of recent oesophageal/gastric surgery, recent epistaxis, * sinusitis * allergy to local anesthetics * subject refusal

Design outcomes

Primary

Measure	Time frame	Description
Measurement of inspiratory pressure, pressure in a hypopharynx and pleural pressure estimation using oesophageal catheter on conventional non-invasive ventilation (NIV).	1 hour	Using measurement of several pressures - inspiratory, oesophageal, nasopharyngeal (cm of H20 on conventional NIV.
Measurement of inspiratory pressure, pressure in a hypopharynx and pleural pressure estimation using oesophageal catheter on High flow nasal oxygenation (HFNO).	1 hour	Using measurement of several pressures - inspiratory, oesophageal, nasopharyngeal (cm of H20) on High flow nasal oxygenation (HFNO).
Calculation of Pressure Time Product (PTP) for estimation of Work of Breathing (WOB).	up to 8 weeks	Compare PTP between conventional NIV and HFNO.
Monitoring of EIT during spontaneous ventilation on conventional non-invasive ventilation (NIV).	1 hour	EIT for description of distribution of ventilation on conventional NIV at different levels of PEEP (cm H20).
Monitoring of EIT during spontaneous ventilation with High flow nasal oxygenation (HFNO).	1 hour	EIT for description of distribution of ventilation with HFNO with different flow rate levels (litres per minute).

Countries

Czechia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026