Liver Metastasis Colon Cancer
Conditions
Brief summary
A few studies have documented that some patients can be down-staged from an initially inoperable state to a potentially resectable state. Five-year survival in initially inoperable patients that ultimately come to a complete resection appears to be similar to patients who are resected at first presentation. The investigators goal is to assess the rate of conversion to complete resection in patients with initially inoperable liver-only metastases due to colorectal cancer after treatment with HAI of oxaliplatin with FOLFIRI and bevacuzimab systemic treatment.
Interventions
DRUGoxaliplatin
intra-arterial oxaliplatin administration
DRUGFOLFIRI Protocol
systemic FOLFIRI chemotherapy
DRUGBevacizumab
systemic bevacuzimab therapy
Sponsors
Rabin Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Subject Inclusion Criteria: * Histologically confirmed colorectal adenocarcinoma metastatic to the liver. * The patient must have inoperable liver metastases as agreed upon by any two hepatobiliary surgeons and the assigned radiologist. * A patient may have had prior chemotherapy or be previously untreated. * ECOG PS \<2 Subject
Exclusion criteria
* Prior radiation, hepatic thermo ablation or resection (other than biopsy) to the liver. * Patient may not have received prior treatment with hepatic artery infusion (HAI). * Extrahepatic metastases * Female patients who are pregnant or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| conversion rate to complete resection in patients with initially inoperable liver-only metastases due to colorectal cancer after treatment with HAI of oxaliplatin with FOLFIRI and bevacuzimab systemic treatment. | 2 years |
Countries
Israel
Contacts
Primary ContactEran Sadot, MD
Outcome results
None listed