Deep Learning Algorithms for Prediction of Lymph Node Metastasis and Prognosis in Breast Cancer MRI Radiomics (RBC-01)

Conditions

Axillary Lymph Node, Breast Neoplasm Female, Early-stage Breast Cancer, Radiomics, Survival, Prosthesis

Keywords

Early-stage Breast Cancer, Radiomics, Axillary lymph node metastasis, Tumor microenvironment, Survival, Deep learning

Brief summary

This bi-directional, multicentre study aims to assess multiparametric MRI Radiomics-based prediction model for identifying metastasis lymph nodes and prognostic prediction in breast cancer.

Detailed description

Sensitivity for prediction of lymph node metastasis and survival of currently available prognostic scores in limited. This study proposes to establish a deep learning algorithms of multiparametric MRI radiomics and nomogram for identifying lymph node metastasis and prognostic prediction of breast cancer. The study will investigate the relationship between the radiomics and the tumor microenvironment. The study includes the construction of multiparametric MRI radiomics-based prediction model and the validation of the prediction model.

Yu Y, He Z, Ouyang J, Tan Y, Chen Y, Gu Y, Mao L, Ren W, Wang J, Lin L, Wu Z, Liu J, Ou Q, Hu Q, Li A, Chen K, Li C, Lu N, Li X, Su F, Liu Q, Xie C, Yao H.

2021-07-04187 citations

10.1016/j.ebiom.2021.103460

Machine learning radiomics signature on magnetic resonance imaging associated with phenotypes and disease-free survival in patients with breast cancer (RBC-01): A registry-based, multicenter cohort study.

Herui Yao, Yunfang Yu, Yujie Tan, Qiugen Hu, Jie Ouyang et al. (20 authors)

Journal of Clinical Oncology2020-05-20

10.1200/jco.2020.38.15_suppl.3563

Abstract OT3-02-02: Radiomics of multi-parametric MRI associated with axillary lymph node metastasis and prognostic in patients with breast cancer: A multicenter RBC-001 study

Herui Yao, Yujie Tan, Yunfang Yu, Chuanmiao Xie, Qiugen Hu et al. (14 authors)

Cancer Research2020-02-15

10.1158/1538-7445.sabcs19-ot3-02-02

Interventions

OTHERNo interventions

As this is a patient registry, there are no interventions.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 75 Years

Healthy volunteers

No

Inclusion criteria

* The primary lesion was diagnosed as invasive breast cancer * Patients can have regional lymph node metastasis,but no distant organ metastasis * Complete the breast MRI examination before treatment * Accept breast cancer surgery or lymph node biopsy * Eastern Cooperative Oncology Group performance status 0-2

Exclusion criteria

* Inflammatory breast cancer * Accompanied with other primary malignant tumors * Perform surgery,radiotherapy and lymph node biopsy before breast MRI examination * Patients who have neoadjuvant chemotherapy * Patients had distant and contralateral axillary lymph node metastasis * The pathologic diagnosis was extensive ductal carcinoma in situ

Design outcomes

Primary

Measure	Time frame	Description
Disease free survival (DFS)	5 years	Disease free survival (DFS), which defined as the time from the diagnosis of breast cancer to the confirmed time of metastatic disease, or death due to any other cause.

Secondary

Measure	Time frame	Description
The correlation of radiomics features and tumor microenvironment	baseline (Completed MRI data before biopsy,surgery,neoadjuvant and radiotherapy.)	Radiomics is a tool to analyze tumor microenvironment characteristics based on breast MRI images.
Lymph node metastasis	Baseline	The value of Radiomics of multiparametric MRI in predicting axillary lymph node metastasis.
Overall survival (OS)	5 years	The association between Radiomics of multiparametric MRI and overall survival (OS), which defined as the time from the beginning of diagnosis of breast cancer to the death with any causes.
Beast cancer specific motality (BCSM)	5 years	Defined as time between randomization and the time of death occur specific due to breast cancer
Recurrence free survival (RFS)	5 years	defined as time between randomization and the time of any recurrence of ipsilateral chest, breast, regional lymph node recurrence, distant metastases, or death occurred

Countries

China

Contacts

Primary ContactHerui Yao, PhD

yaoherui@mail.sysu.edu.cn+8613500018020

Backup ContactYunfang Yu, MD

yuyf9@mail.sysu.edu.cn+8613660238987

Outcome results

None listed