Embryo Implantation
Conditions
Brief summary
Our study intends to demonstrate that the selection of an embryo to transfer it at the sage of blastocyst through morphokinetics (analysis of embryos depending not only in their morphology -that is, the aspect of the embryo-, but also based on times of cell division) during the use of time-lapse (Embryoscope®) may have a better impact in clinical results, as selection is not performed in mere morphological evolution (visual aspect of the embryo) of the embryos.
Detailed description
Our study intends to demonstrate that the selection of an embryo to transfer it at the sage of blastocyst through morphokinetics (analysis of embryos depending not only in their morphology -that is, the aspect of the embryo-, but also based on times of cell division) during the use of time-lapse (Embryoscope®) may have a better impact in clinical results, as selection is not performed in mere morphological evolution (visual aspect of the embryo) of the embryos. In order to obtain this objective, patients participating in the study will be randomly assigned to one of the following groups: Group A: Patients who will perform an embryo transfer of a blastocyst using morphological criteria to evaluate que quality of the blastocyst (Gardner Classification), that is, based on the aspect or form of the embryo. Group B: Patients who will perform an embryo transfer of a blastocyst using morphokinetics criteria to evaluate the quality of the blastocyst (Embryoscope®), that is, based not only in the aspect of the embryo but also in cell division times experimented by the embryos.
Interventions
OTHERMorpho-kinetics selection with time-lapse (Embryoscope) evaluation
Embryos in group B will be selected in blastocyst stage according to morpho-kinetics criteria before the embryo transfer
Sponsors
Sociedad Espanola Fertilidad
Procreatec
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Masking description
Once patients accept to be enrolled in the study, one of the nurses will allocate the patient to one of study groups. Neither the patient nor the doctor will know the group assigned.
Intervention model description
Two arms interventional prospective randomized controlled trial.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Egg-donation IVF patients * IVF patients if \< 38 years * Sperm concentration \> 2 million/ml * Frozen eggs for * Single embryo transfer * ICSI fertilization
Exclusion criteria
* Uterine pathologies that may interfere with implantation * Endometriosis * Frozen eggs * Pre implantation genetic testing of the embryos * Day 3 embryo transfer * Conventional IVF treatments
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pregnancy Rate | 12-14 days after the embryo transfer | Positive pregnancy test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical Pregnancy Rate | 12-15 days after the positive blood test for pregnancy | US pregnancy confirmation |
Countries
Spain
Contacts
Primary ContactEster Padilla
Backup ContactLourdes Lopez
Outcome results
None listed