Nebulized Lidocaine to Prevent Cough at Emergence From Anesthesia

Nebulized Lidocaine Versus Placebo to Prevent Cough at Emergence From Anesthesia: a Double Blind Prospective Randomised Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04000633

Enrollment

Registered

2019-06-27

Start date

2019-06-01

Completion date

2019-12-31

Last updated

2019-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cough, General Anesthesia, Extubation, Lidocaine, Sore Throat

Brief summary

our study aimed to evaluate the effect of nebulized lidocaine to decrease the incidence of cough and sore throat after extubation after surgeries requiring endotracheal intubation.

Detailed description

our study aimed to evaluate the effect of nebulized lidocaine to decrease the incidence of cough and sore throat after extubation after surgeries requiring endotracheal intubation. This randomized controlled study will compare the effect of Lidocaine and placebo nebulization in the immediate pre operative period in order to evaluate the effectiveness in reducing post extubation cough and sore throat.

Interventions

DRUGLidocaine 2%

the patients of this group will recieve nebulization of 5 ml of 2% lidocaine prior to induction of general anesthesia

DRUGNormal saline

Normal saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Caregiver)

Masking description

The investigator will provide to the anesthesiologist 1 seringue containing either lidocaine or normal saline to be nebulized before induction of general anesthesia

Intervention model description

2 groups comparaison between nebulized lidocaine versus placebo for prevention of cough at emergence from general anesthesia and post extubation sore throat

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* age\>18 years * ASA status I or II

Exclusion criteria

* Unexpected difficult laryngoscopy * Surgery\>3 hours

Design outcomes

Primary

Measure	Time frame	Description
incidence of cough at emergence from general anesthesia	30 minutes after the end of surgery	evaluation of incidence of cough at emergence from general anesthesia

Secondary

Measure	Time frame	Description
incidence of sore throat	24 hours after tracheal extubation	evaluation of incidence of sore throat

Countries

Tunisia

Contacts

Primary ContactMhamed Sami Mebazaa, professor

msmebazaa@gmail.com0021622252589

Backup ContactHajer Arfaoui

hejer_arfaoui@hotmail.fr0021699336661

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026