Infarction, Myocardial, Ventricular Arrythmia
Conditions
Keywords
electrical impedance, cardiac radiofrequency ablation
Brief summary
Precise identification of the infarct scar is essential for successful catheter ablation of ventricular arrhythmias in patients with chronic myocardial infarction. Voltage mapping of endocardial electrograms is currently used to delineate the necrotic scar but this is influenced by the direction of the activation wave front and is not sensitive enough to differentiate distinct degrees of transmural injury in the scar. Mapping of local myocardial electrical impedance may overcome these limitations.
Detailed description
Clinical series: Patients with chronic infarction undergoing catheter ablation of ventricular arrhythmias will be submitted to mapping of both voltage and tissue impedance. Likewise, the accuracy of the two maps identifying the extent and transmurality of the infarction will be assesssed by gadolinium imaging. The impedance system is already constructed and certified for clinical research use.
Interventions
DEVICECardioZ multifrequency impedance recording system
Patients will be submitted to mapping of both voltage and tissue impedance. The accuracy of the two maps identifying the extent and transmurality of the infarction will be assesssed by gadolinium imaging.
Sponsors
Universitat Politècnica de Catalunya
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* More than 18 yearts * Chronic myocardial infarction * Undergoing ventricular ablation of ventricular arrhythmias
Exclusion criteria
* patients with device not suitable for cardiac magnetic ressonance (CMR) * pregnacy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparative detection of infarct scar by voltage mapping | 3 hours | Voltage will be measured at different sites of the infarct scar and healthy tissue. |
| Comparative detection of infarct scar by impedance mapping | 3 hours | myocardial local impedance will be measured at different sites of the infarct scar and healthy tissue. |
| Comparative detection of infarct scar by gadolinium enhanced MR imaging | 30 minutes | Intensity of gadolinium will be measured at different sites of the infarct scar and healthy tissue. |
Countries
Spain
Contacts
Primary ContactJuan Cinca Cuscullola, Professor
Backup ContactLaia Angli
Outcome results
None listed