Freeze-all Policy in Poor Responders

Fresh Versus Frozen Embryos for Infertility in the Poor Responders as Defined by the Bologna Criteria

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03999541

Enrollment

178

Registered

2019-06-26

Start date

2019-07-30

Completion date

2020-12-30

Last updated

2020-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility, Female

Brief summary

To compare the effects of fresh embryo transfers (ET) and elective frozen-thawed embryo transfer cycles in poor ovarian responders.

Interventions

OTHERFreeze-all policy

A policy of freezing all the embryos followed by subsequent thawed frozen embryo transfer

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Masking description

Blinding of the allocated intervention is not possible.

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* All patients that fulfill the Bologna criteria \[at least 2 of the following 3 features must be present: (i) advanced maternal age or any other risk factor for POR; (ii) a previous POR; and (iii) an abnormal ovarian reserve test (ORT)\] * if the progesterone serum level was ≤1.5 ng/mL on the trigger day. * body mass index 18-32 kg/m2 * Both partners are able to provide written informed consent. * At least 1 good quality embryo on day 3 after egg collection on day 3 according to the Istanbul consensus (7-8 cells; with symmetric blastomeres and \<10% fragmentation by volume). * Endometrial thickness ≥8 mm on trigger day. * a normal uterine cavity on ultrasound. * IVF/ICSI with only fresh semen

Exclusion criteria

* Pre-implantation genetic testing is being planned. * if they had severe endometriosis, uterine pathology (myomas, adenomyosis, endocrinopathies, adhesions, acquired or congenital abnormalities), untreated tubal hydrosalpinges, ovarian tumor, recurrent spontaneous abortion, implantation failure after ≥ 2 fresh or frozen ET.

Design outcomes

Primary

Measure	Time frame	Description
Livebirth rate	32 weeks	The proportion of women in the population who had at least one live baby.

Secondary

Measure	Time frame	Description
Pregnancy rate	2 weeks	Positive pregnancy test at two weeks +/- three days after embryo transfer
Clinical pregnancy rate	6-8 weeks	The presence of at least one fetal heartbeat at ultrasound between six and eight weeks of gestation

Countries

Egypt

Contacts

Primary ContactYasmin Magdi, PhD

Yas.magdi@hotmail.com00201282313979

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026