Osteoporosis, Rheumatoid Arthritis
Conditions
Keywords
14-3-3η Protein
Brief summary
Is to investigate the relation between 14-3-3η protein, disease activity, and bone mineral density in female patients with rheumatoid arthritis.
Detailed description
Methods: all patients in the study will subject to: * Clinical assessment, WT, Height ,BMI, parity, medications, * DAS 28. * Serum 14-3-3η protein. * DEXA scan. Grouping: * Group I: RA Patients with low BMD. * Group II: RA Patients with normal BMD. * Group III: normal control.
Interventions
DIAGNOSTIC_TEST14-3-3η Protein assay
blood sampling for assessment of serum 14-3-3η Protein
Sponsors
Al-Azhar University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
16 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Rheumatoid arthritis according to ACR 2010 criteria with at least one year duration. * Premenopausal females. * On conventional DMARD with maximum 5 mg steroids.
Exclusion criteria
* Biological treatment. * Previous antiresorptive treatment, or bone anabolics. * High dose corticosteroid. * Chronic renal or kidney disease. * Medications affecting bone metabolism. * Thyroid or adrenal dysfunction,
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 14-3-3η Protein and RA disease activity | three months | percent of active RA disease and study the correlation between 14-3-3η Protein and RA disease activity |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 14-3-3η Protein and osteoporosis in RA patients | three months | percent of low BMD and study the correlation between 14-3-3η Protein and osteoporosis in RA patients |
Countries
Egypt
Outcome results
None listed