Heart Failure
Conditions
Keywords
diuretics
Brief summary
We will conduct a pragmatic randomized trial comparing whether using a combination of two types of diuretics (loop + thiazide) compared with using a single diuretic (loop only) will result in shorter hospital stays for patients hospitalized with heart failure.
Interventions
DRUGLoop Diuretics vs. loop + thiazide diuretics
Participants will receive the diuretic type as determined by the randomized group assignment starting within the first 24 hours of hospital admission and continuing for up to 72 hours. All other treatments are left to the discretion of the treatment team, as this is a pragmatic randomized trial.
Sponsors
American Heart Association
Stanford University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Any adult (age ≥18 years) admitted to the Heart Failure Service at Stanford Health Care with an indication for treatment with a diuretic.
Exclusion criteria
1. admission to the intensive care unit or cardiac care units 2. maintenance dialysis on admission 3. any mechanical circulatory support on admission 4. history of heart transplant 5. allergy / intolerance to loop or thiazide diuretics 6. admission serum sodium \< 125 meq/L (from EPIC) 7. admission serum potassium \< 3.0 meq/L (from EPIC)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital length of stay | During hospitalization up to 90 days |
Secondary
| Measure | Time frame |
|---|---|
| Composite of all-cause rehospitalizations, emergency department visits, or death in the 30 days after hospital discharge. | 30 days |
Countries
United States
Outcome results
None listed