Colorectal Neoplasms
Conditions
Brief summary
Recruit of healthy, precancer and colorectal cancer patients and record necessary information of demographic and also other messages. All the volunteers were asked to provide samples including stool, blood, urine and tissues. This protocol is performed with the permission of the ethics committee and all the participants were provided with informed consent.
Detailed description
Healthy subjects, precancer patients identified by colonoscopy or colonoscopy history and colorectal cancer patients identified by two independent pathologists will be enrolled. The demographic message including age, weight, height, drug history, family history of all participants will be recorded. Blood, stool and urine samples will be collected of all subjects. Tumor and adjacent tissue samples of colorectal cancer and precancer patients were collected, as well as normal tissue of healthy subjects.
Interventions
None listed
Sponsors
Shanghai 10th People's Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. individuals who were clear and signed the informed consent. 2. Male and female. 3. Age \>18
Exclusion criteria
1. Any one who can not provide accurate information. 2. Any one who denies the study. 3. Younger than 18.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gut microbiota structure and function difference between colorectal cancer, precancer and healthy controls | average of 5 years | The results were based on the 16S rRNA metagenomic sequencing. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic difference of blood samples between colorectal cancer, precancer and healthy controls | average of 5 years | The metabolites of the blood samples by LC-MS will be detected. |
Countries
China
Contacts
Primary ContactHuanlong Qin, Ph.D
Outcome results
None listed