Candidiasis, Invasive, Critically Ill, Intra Abdominal Infections, Peritoneal Candidiasis
Conditions
Brief summary
New rapid diagnostic strategies are warranted in intra-abdominal candidiasis (IAC). A previous retrospective study showed that one measure, the day of the surgery, of peritoneal 1.3-Beta-D-Glucan ≤ 310pg/ml could rule out an IAC. This strategy was independent of the patient underlying conditions and Candida risk factors. This study aimed to confirm these results with a multicenter prospective study
Interventions
DIAGNOSTIC_TEST1.3 BETA D GLUCAN
dosage of 1.3 BETA D GLUCAN in the peritoneal fluid obtained during surgery with the β-glucan test (Fujifilm Wako Chemicals, Osaka, Japan)
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* critically ill adult (\> 18 yrs old) admitted to ICU for intra-abdominal infection requiring surgery and possible intra abdominal candidiasis
Exclusion criteria
* declinate to participate, * expected death within the first 24 hours
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure of 1.3 BDG in the peritoneal exudate of patient with intra-abdominal candidiasis | 1 DAY | Value of 1.3 BDG in the peritoneal exudate in patient with intra-abdominal candidiasis in comparison with non intra-abdominal candidiasis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measure of 1.3 BDG in the serum of patient with intra-abdominal candidiasis | DAY 1 and DAY 3 | Coefficient of correlation between peritoneal and serum 1.3 BDG in patient with and without intra-abdominal candidiasis |
Countries
France
Outcome results
None listed