Hearing Loss, Sensorineural
Conditions
Brief summary
Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models. This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.
Interventions
OTHERPeroperative collect of inner ear cells
After obtaining an informed consent during the preoperative medical visit, and if a non-conservative approach (translabyrinthine or transotic) is decided, the collect of inner ear cells will be performed during surgical approach. The sample will be collect in a sterile tube, and carried to the laboratory were it will be placed bon cell culture.
Sponsors
Assistance Publique - Hôpitaux de Paris
Institut Pasteur
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient ≥ 18 years old * Operative indication for a non-conservative resection of vestibular schwannoma, decided by the surgeon in accordance with the patient * Informed consent obtained * Patients with a french social protection (AME excluded)
Exclusion criteria
* Intravestibular or intra-cochlear extension of the tumor * Pregnant woman * Patient with administrative control * Medical contra-indication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| AAV transduction in inner ear cells | 10 days | The transduction will be measured with immunostaining techniques |
Countries
France
Contacts
Primary ContactGhizlene Lahlou
Backup ContactSaaid Safieddine
Outcome results
None listed