Amyloidosis Cardiac, Carpal Tunnel Syndrome
Conditions
Brief summary
Wild-type transthyretin cardiac amyloidosis is an underdiagnosed depository disease in which fibril monomers of misfolded amyloid protein accumulates in various tissues, including the heart, and cause tissue dysfunction. Before onset of cardiac symptoms, many patients will have undergone surgery for idiopathic carpal tunnel syndrome since the protein also deposits in the transversal carpal ligament of the hand. This study investigates patients previously operated for idiopathic carpal tunnel syndrome to determine if they display signs and symptoms of cardiac amyloidosis.
Interventions
DIAGNOSTIC_TESTDPD Scintigraphy
Confirms/Refutes diagnosis of cardiac amyloidosis.
Sponsors
Regional Hospital Holstebro
Aarhus University Hospital Skejby
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients above sixty years of age previously operated for idiopathic carpal tunnel syndrome within the Region of Central Denmark (Region Midtjylland) the last five years. * Informed written and verbal consent
Exclusion criteria
* Operation by different indication such as * Fracture * Ganglion * Tumors * Osteophytes * Rheumatoid Arthritis * Persistent medial artery * Metabolic causes * Alcoholism * Hyperthyroidism * Myxedema * Hereditary Cardiac Amyloidosis * Known WT ATTR * AL Amyloidosis * Myelomatosis * MGUS and Morbus Waldenström
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of cardiac amyloidosis. | Through study completion, an average of 2 years. | The prevalence of cardiac amyloidosis among patients previously operated for ipiopathic carpal tunnel syndrome. |
Countries
Denmark
Outcome results
None listed