Allergy, Child Development, Growth, Infectious Disease, Noncommunicable Diseases, Overweight
Conditions
Keywords
Birth cohort, Intestinal microbiota, Child health
Brief summary
The aim of this cohort is to identify environmental, lifestyle and genetic factors that modify the human intestinal microbiota development during the first years of life, and to identify early microbiota features that associate to child health and well-being with focus on the development of allergic diseases and overweight.
Detailed description
1055 healthy term infants born in 2016-2018 mainly at the capital region of Finland, and their parents. Fecal samples collected from infants and their parents. Electronic questionnaires on a weekly basis during the first 4 months of life, thereafter less frequently. Focus on diet, well-being and health and social manners. At one-year and at two-years comprehensive questionnaires including development and cognition. Parental stress evaluation included.
Interventions
None listed
Sponsors
Business Finland
Valio Ltd
Finnish Red Cross Blood Service
DuPont Nutrition and Health
Oriola Corporation
Pikkujätti Medical Centre for Children and Youth
University of Helsinki
Study design
Observational model
FAMILY_BASED
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* General population, singleton pregnancy, at least one parent Finnish speaking * Willingness and ability of parents to consent for 2 year follow-up involving frequent electronic questionnaires and freezing of faecal samples at home * Infant born on gestational weeks 37-42 without known congenital defects
Exclusion criteria
* Preterm birth * Severe birth defect * Parents fail to activate the online questionnaires
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Longitudinal change of intestinal microbiota in early life | From 3 weeks to 2 years after birth | Developmental trajectory of the intestinal microbiota, assessed with 16S rRNA gene amplicon and shotgun sequencing of fecal DNA to determine the changes in the intestinal microbiota composition, diversity and functionality from week 3 to weeks 6,9,12 and months 6,9,12,18 and 24 after birth. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of children with allergic disease | At 2 years | Specialist/Physician-diagnosed wheeze, eczema/atopic dermatitis, allergic rhinitis, food allergy or atopy. |
| Number of respiratory tract infection episodes | From birth to 2 years of age | Number of physician-diagnosed respiratory track infections. |
| Number of children with asthma | At 2 years | Specialist/Physician-diagnosed asthma. |
| Growth | At 6,12,18 and 24 months after birth | Height in centimeters. |
| Child development | At 18 and 24 months after birth | By means of questionnaires and, on a randomly selected group of study subjects, developmental testing to assess cognitive, motor, socio-emotional and verbal development. |
| Weight | At 6,12,18 and 24 months after birth | Weight in kilograms. |
Countries
Finland
Outcome results
None listed