Peripheral Arterial Disease
Conditions
Brief summary
I. To investigate whether patient characteristics, exercise therapy characteristics, local metabolic exercise response, endothelial function, autonomic function or atherosclerotic lesion location can predict the walking response to a successfully completed semi-supervised exercise intervention in patients with intermittent claudication (WP I) II. To assess the effect of a home-based exercise intervention with remote monitoring and coaching on cardiovascular risk factors in patients with intermittent claudication (WP II)
Interventions
OTHERWalking
Technology-guided semi-supervised walking therapy
OTHERControl
Go Home and Walk advice
Sponsors
KU Leuven
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
The study population will comprise patients diagnosed with lower-extremity artery disease (ABI ≤0.9 and/or 20% decrease after a maximal treadmill test) suffering from intermittent claudication (Rutherford 1-3) presenting with new complaints (at least 6 months after previous revascularization) at the Vascular Center of university hospitals Leuven will be included if according to current guidelines their initial treatment should be conservative Inclusion Criteria: * age \> 17 yrs * ABI ≤0.9 and/or 20% decrease after a maximal treadmill test * intermittent claudication (Rutherford 1-3) * ability to undertake an exercise test and read and understand Dutch questionnaires
Exclusion criteria
* exercise test induced signs of complex arrhythmias or significant ischemia during baseline testing * other comorbidity limiting participation in the exercise group
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain free walking distance | Baseline - 12 weeks | Treadmill protocol |
Countries
Belgium
Outcome results
None listed