Cerebrovascular Disease, Ischemic Stroke
Conditions
Brief summary
This research project aims at contributing to improve TIA diagnosis and management by using PREDISC scores and specific biomarkers thought to have elevated levels in TIA patients. A swift and accurate TIA diagnosis allows starting treatment of the patient adequately and shortly after the event. The shorter the time between the event and treatment onset, the better the outcome. This approach will be an important step forward in TIA diagnosis and management, similarly to acute coronary syndrome as discussed above.
Interventions
None listed
Sponsors
Ente Ospedaliero Cantonale, Bellinzona
Dr. med. Carlo Cereda
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with suspected TIA (defined as the acute onset of focal neurological symptoms lasting \<24 h and presumed to be caused by brain ischemia at the time of referral) within 48 h of symptoms onset. * At least 18 years old. * Having given their Informed Consent.
Exclusion criteria
* · Patients with ocular TIA (Amaurosis fugax). * Patients that still have neurological deficits at the moment of inclusion. * Contraindication to perform MRI. * For women: pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Levels of specific biomarkers (Platelet Basic Protein (PBP), ceruloplasmin, microRNAs, exosomal particles) in patients with suspected TIA. | 1 year | Diagnostic performance according to PREDISC scale |
Countries
Switzerland
Outcome results
None listed