Head and Neck Cancer, Multiparametric MRI, Cervical Lymph Node
Conditions
Brief summary
The investigators aim to identify specific MRI parameters that could improve diagnostic accuracy of metastatic cervical lymph nodes in patients with a squamous cell carcinoma in the head and neck region.
Detailed description
Background:The locoregional control rates in patients with advanced head and neck cancer remain suboptimal. Accurate diagnosis of metastatic cervical lymph nodes remains challenging. Technological advances in magnetic resonance imaging (MRI) enable to quantify diffusion and perfusion of the tumour and its surrounding tissues, which could improve diagnostic performance. Objectives: The investigators aim to identify specific MRI parameters that could improve diagnostic accuracy of metastatic cervical lymph nodes in patients with a squamous cell carcinoma in the head and neck region. Study design: a retrospective study will be set up to explore the diagnostic performance of the selected MRI parameters to differentiate between tumoural and non-tumoural cervical lymph nodes in patients with a histologically confirmed head and neck tumour ('affected group') or histologically confirmed Whartin tumour or pleomorphic adenoma of the parotid gland, without malignant transformation ('control group'). Patients will be screened for inclusion in the analysis if they had a routine preoperative multiparametric MRI, according to a standardised protocol, between the 1st of December 2016 and the 30th of September 2018. All MR images will be screened by the resident to select those patients with one or multiple clearly distinguishable metastatic cervical lymph node(s), which can be clearly correlated with the final pathology report. Other strict inclusion criteria are described in detail in the protocol.
Interventions
OTHERmultiparametric MRI
preoperative multiparametric MRI
Sponsors
AZ Sint-Jan AV
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients that received a pretreatment multiparametric MRI according to a standardized protocol between December 2016 and December 2018 * histophatologically proven SCC in the head and neck region * one or multiple clearly distinguishable cervical lymph node(s), that can be unambiguously correlated with the pathology report
Exclusion criteria
* patients not fulfilling abovementioned criteria * patients with thyroid or skin cancer * considerable artefact on MRI * previous surgery, irradiation or chemotherapy in the HN region
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| discriminatory value of MRI perfusion curve | preoperative | differentiation between a metastatic cervical lymph node and a non-tumoural lymph node, as based on the final pathology report as the 'gold standard' |
| discriminatory value of MRI ADC | preoperative | differentiation between a metastatic cervical lymph node and a non-tumoural lymph node, as based on the final pathology report as the 'gold standard' |
| discriminatory value of MRI D-value | preoperative | differentiation between a metastatic cervical lymph node and a non-tumoural lymph node, as based on the final pathology report as the 'gold standard' |
Outcome results
None listed