Effect of Vitamin D on the Size of Fibroids in Women With Vitamin D Deficiency

Pilot Clinical Study to Evaluate the Effect of Vitamin D on the Size of Fibroids in Women With Vitamin D Deficiency

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03991078

Enrollment

Registered

2019-06-19

Start date

2019-07-09

Completion date

2024-12-25

Last updated

2025-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Size of the Uterine Fibroids

Brief summary

Vitamin D supplementation in patients with uterine fibroids who present hypovitaminosis D to re-establish their normal serum values could stabilize the size of the uterine fibroids and thus prevent their growth or reduce their size thanks to the anti-proliferative action of Vitamin D on the myoma cells.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Diagnosed with at least one fibroid \> 3 cm * With hypovitaminosis D (25(OH)D \< 30 ng/ml) * BMI \< 30 * No hormonal treatment in the 3 months prior to the ultrasound study

Exclusion criteria

* Black race * Symptomatic fibroids subsidiary to hormonal or surgical treatment * Desire of gestation in the next 6 months * Presence of degenerating adenomyosis or fibroids * Treatment with sexual hormones: mifepristone, aGnRH or any other medication that may interfere with fibroids. * History of neoplasia of gynecological origin and/or existence of uterine malformations. * Hypercalcemia or abnormal liver or kidney function is present

Design outcomes

Primary

Measure	Time frame
volume of the uterine fibroids	3 months

Countries

Spain

Outcome results