Hepcidin
Conditions
Brief summary
Iron deficiency is one of the most common nutritional problems observed in patients with obesity and after bariatric surgery. From a therapeutic point of view, iron deficiency can lead to iron deficiency anemia. Iron supplementation carries the risk of exacerbating infections, altering the gut microbiome and iron overload. Therefore, it would be beneficial to use iron supplementation only in truly iron deficient patients. To date, different studies have observed that hepcidin could be a possible indicator of iron status and absorption in different patient populations. Furthermore, it could be used to distinguish anemia due to iron deficiency from inflammation and globin disorder related anemia. How hepcidin concentrations variate in patients with obesity and after bariatric surgery remains unsure.
Detailed description
During the visit in the obesity clinic, eligible patients will be approached for participation by the sub-investigator. Interested patients will receive information regarding the study and receive the information sheet containing the informed consent form. After signing the informed consent form, general information will be collected regarding medical and demographic data using a short questionnaire. Additional questionnaires regarding demographics and menstrual cycle will be collected. Anthropometric measurements will be collected for the determination of the length, weight, hip circumference, waist circumference and body composition. Finally, blood samples will be collected for the determination of iron and inflammation related markers.
Interventions
OTHERBlood sampling
Blood sample collection
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* The patient has to be 18 years or older * Written informed consent has to be obtained after being informed on all aspects of the study * The patient has a BMI \> 30 kg/m² OR There has to be at least one year between the primary RYGB and the participation in the study OR There has to be at least one year between the primary SG and the participation in the study
Exclusion criteria
* Patients younger than 18 years old * Women who are pregnant or are breastfeeding * Post-menopausal women, defined as at least 6 months of amenorrhea after the final menstrual period * Inability to follow the procedures of the studies due to language problems * Patients who have had more than one bariatric surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum hepcidin concentration | Study visit 1 day | Serum hepcidin concentration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean corpuscular volume | Study visit 1 day | Mean corpuscular volume |
| Iron concentration | Study visit 1 day | Iron concentration |
| Ferritin concentration | Study visit 1 day | Ferritin concentration |
| Transferrin concentration | Study visit 1 day | Transferrin concentration |
| Hemoglobin concentration | Study visit 1 day | Hemoglobin concentration |
| C-reactive protein | Study visit 1 day | C-reactive protein |
| Vitamin B12 concentration | Study visit 1 day | Vitamin B12 concentration |
| Folate (RBC level) | Study visit 1 day | Folate (RBC level) |
| Folate (serum level) | Study visit 1 day | Folate (serum level) |
| Transferrin saturation | Study visit 1 day | Transferrin saturation |
Countries
Belgium
Outcome results
None listed