Frontal Lobe Oxyhemoglobin Levels in Patients With Lower Extremity Burns Assessed Using a fNIRS

Frontal Lobe Oxyhemoglobin Levels in Patients With Lower Extremity Burns Assessed Using a Functional Near-Infrared Spectroscopy Device During Usual Walking: A Pilot Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03990831

Acronym

fNIRS

Enrollment

Registered

2019-06-19

Start date

2019-07-09

Completion date

2019-07-09

Last updated

2019-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Walking

Keywords

Burn, Near-infrared spectroscopy (NIRS)

Brief summary

Investigators investigate the patterns of cortical activation using the NIRST in patients with peripheral neurological injury caused by lower extremity burns.

Detailed description

Understanding the mechanisms associated with locomotor networks may be of benefit for rehabilitation of burn victims with neurological locomotor deficits. However, the effects of peripheral neurological injury on locomotor network remains unknown. A wearable functional near-infrared spectroscopy (fNIRS) device has been developed for studying cortical hemodynamics. Changes in cortical activity has not previously been documented in patients with burn injury. Investigators assessed 15 patients with lower extremity burns and 11 healthy controls. Investigators measured walking-related cortical activity using an fNIRS device at baseline and during usual walking. Cortical activity was measured by evaluating relative changes in oxyhemoglobin level. The NIRST Analysis Tool v2.1 was utilized to analyze fNIRS data in a MATLAB environment.

Interventions

DIAGNOSTIC_TESTFunctional near-infrared spectroscopy (fNIRS)

Functional near-infrared spectroscopy (fNIRS) measurement

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Intervention model description

patients with lower extremity burn : 15 patients patients with upper extremity burn : 10 patients healthy controls : 11

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* burn patients with lower extremity or upper extremity thermal injury * patients who could walk unassisted for at least 5min.

Exclusion criteria

* patients with critical systemic conditions * severe cognitive impairment * had severe pain * unable to walk.

Design outcomes

Primary

Measure	Time frame	Description
oxygenated hemoglobin (HbO2) of the prefrontal regions,	5 minutes	identify the location of the normal cortical activation during usual walking

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026