Acute Stroke, Intracranial Atherosclerosis, Transient Ischemic Attack
Conditions
Keywords
intracranial atherosclerotic disease, acute stroke, transient ischemic attack, vessel wall imaging
Brief summary
Despite advances in stroke care, women continue to face worse outcomes after stroke than men. This disparity in outcomes may be related to biologic sex-differences that manifest in the development and progression of atherosclerosis. Decades of cyclic changes in the hormonal milieu lead to different metabolic profiles in women. These changes may also explain sex-differences in risk factor profiles of atherogenesis and plaque composition. The investigators' objective is to conduct a cross-sectional MR imaging study of suspected stroke patients to compare the burden and composition of intracranial atherosclerosis and risk factors between men and women. Results from this study are expected to show that sex and sex-specific risk factors should be considered at the outset of stroke evaluation for risk-stratification. In the era of precision medicine, the investigators propose the role of sex should be a starting point in the clinical evaluation of stroke.
Interventions
None listed
Sponsors
University of Pennsylvania
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Older than 18 years * Suspected stroke patients * No contraindications for an MRI exam or gadolinium intravenous contrast * No need for an emergent interventional treatment (e.g., thrombectomy)
Exclusion criteria
* Younger than 18 years * Pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of intracranial arterial wall abnormalities by sex. | 1 day (Evaluated at time of clinical presentation). | Vessel wall imaging characteristics on multicontrast MR imaging |
Countries
United States
Outcome results
None listed