Polyp Colorectal
Conditions
Brief summary
There is no evidence to prove the impact of post-procedural diet on post-polypectomy bleeding (PPB) or delayed perforation. No relevant study has been conducted and it is yet to be determined if absolute diet is necessary for post-polypectomy patients, and the comparison between normal diet and absolute diet also remains unclear. Therefore, we carried out this randomized controlled study to evaluate and compare tthe clinical effect of different diets on post-polypectomy patients.
Interventions
DIETARY_SUPPLEMENTabsolute diet
Patients in absolute diet group were fasted from any food with intravenous infusion of 5% glucose and sodium chloride instead in the first 24 hours. Then, the patients will be given soup for the next 24 hours if there was no delayed complication or discomfort during the fasting. Finally, they will gradually transit from soup to normal diet such as porridge, noodles and rice in the third 24 hours.
DIETARY_SUPPLEMENTnormal diet
Patients in normal diet group were directly given normal diet such as porridge, noodles and rice as usual after polypectomy. Meanwhile, all the patients in two groups were given PPI for 3 days intravenously and restricted from vigorous exercise for 14 days.
Sponsors
Nanfang Hospital, Southern Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. 18-75 patient with initial diagnosis of colorectal polyp by colonoscopy; 2. The maximum size of polyp is more than 20mm; 3. The patients underwent single ESD procedure for the polyp and agreed to participate this trial.
Exclusion criteria
1. Uncontrollable hypertension or diabetes； 2. Severe comorbidities such as cancer and organ failure etc； 3. Patients who were pregnant; 4. Patients had anticoagulants during perioperative period; 5. Patients with poor compliance. -
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative adverse event rate | 14-day after polypectomy | Postoperative AE includes PPB, post polypectomy electrocoagulation syndrome(PPES) and delayed perforation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| length of stay | 14-day after polypectomy | calculated by subtracting day of admission from day of discharge. |
| hospitalization cost | 14-day after polypectomy | represent the hospital's costs of patients at the hospital |
Outcome results
None listed