Rosacea
Conditions
Keywords
autonomic nervous system, skin blood flow, skin sympathetic nerve activity
Brief summary
Rosacea is a common skin disorder which causes facial redness and inflammation in about 16 million Americans, from an unknown cause. Many triggers of rosacea symptoms are stressors that affect the sympathetic (fight or flight) portion of the nervous system, and a recent pilot study suggests there is sympathetic dysfunction in rosacea. This project will benefit patients, clinicians, and basic scientists by increasing our understanding of sympathetic nervous system involvement in rosacea symptoms in order to develop improved treatments for patients with rosacea.
Interventions
OTHERsystemic and local stressors
Protocol 1: skin sympathetic nerve activity will be measured during mental math and handgrip exercise. Protocol 2: skin end organ responses will be measured at baseline and in response to systemic stressors and end-organ receptor stimulation. Protocol 3: skin end organ responses will be measured at baseline and during local heating.
Sponsors
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Kristen Metzler-Wilson
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Otherwise healthy males and non-pregnant/non-lactating females with mild to moderate erythematotelangiectactic rosacea, as well as age-sex matched healthy control subjects.
Exclusion criteria
* Neurological, cardiovascular, respiratory, metabolic, muscular, or other dermatological disorders * Current history of alcohol and/or drug abuse * Known allergies or hypersensitivities to medications/drugs that are used in the protocol * Current smoking or regular smoking within the last 2 years * Body mass index \> 35 kg/m2 * Medications or supplements which are known to affect neural, cardiovascular, or muscular responses
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skin blood flow | Immediate (during the single-day study). This study consists of a one-day protocol, during which this outcome is measured. | laser Doppler flowmetry |
| Skin sympathetic nerve activity | Immediate (during the single-day study). This study consists of a one-day protocol, during which this outcome is measured. | microneurography |
Countries
United States
Outcome results
None listed