Cognitive Dysfunction
Conditions
Keywords
postoperative Cognitive Dysfunction, hip- and knee arthroplasty, transcutaneous vagus nerve stimulation
Brief summary
This study evaluate the cognitive functions of patient after hip or kneel replacement.Half of the patient will receive transcutaneous vagus nerve electrical stimulation during the surgery while the other half will get placebo therapy
Interventions
DEVICEtranscutaneous vagus nerve electric stimulator
The stimulator that can be attached to ears of the patient.We suppose that this device can reduce the incidence of perioperative neurocognitive disorders(PND)
Sponsors
RenJi Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
65 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* over 65 years old * ability to communication * hip or kneel replacement * willing to participate in the study * ASA I-II
Exclusion criteria
* with cerebral disorders or disease * cognitive impairment before surgery * with mental disease * unable to communication * severe eyes or ears impairment * surgery performed in the past 30 days * Bradycardia，II°AVB，III°AVB，severe heart, liver and kidney dysfunction * severe skin disease * refuse to enter the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of perioperative neurocognitive disorders | one month | make different scale before and after operation to evaluate neurocognitive changes in experiment group and control group. |
Countries
China
Contacts
Primary ContactDiansan Su
Backup ContactYichen Fan
Outcome results
None listed