Plasmodium Knowlesi Infection
Conditions
Keywords
Monkey malaria
Brief summary
This study aims to determine the sensitivity, specificity, and practical value of two new molecular diagnostic assays compared to a more classical nested molecular diagnostic assay and the routine microscopy (both of which are the current gold standard) in detection of P. knowlesi.
Interventions
None listed
Sponsors
Duke University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
7 Years to No maximum
Inclusion criteria
* Suspected for malaria infection; fever (axillary or tympanic temperature ≥ 37.5 °C or oral or rectal temperature of ≥ 38 °C) with chills, worsening malaise, headache lassitude, fatigue, abdominal discomfort, muscle and joint aches, anorexia, perspiration, or vomiting at the time of evaluation or within the past 48 hours * Written informed consent is obtained. * For Children (\>7 to \<18 years): parent or legal guardian provides written informed consent.
Exclusion criteria
* Patients living in, or returning from malaria endemic area outside of Sarawak within 2 weeks of illness onset * They have a clear alternative diagnosis other than malaria by a trained health care professional.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with a possible diagnosis of malaria | 10 weeks | Possible diagnosis of malaria as defined in accordance with the inclusion and exclusion criteria. Giemsa-stained thick and thin smears will be prepared for verification of parasitaemia by microscopy in the respective hospital laboratories |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Statistical association between risk factors and diagnostic assays results. | 10 weeks | A brief enrollment questionnaire will be used to determine a statistical association between demographic and behavioral/occupational risk factors and the assays results combined |
Countries
Malaysia
Outcome results
None listed