Non-opioid Based Pain Control After Thyroidectomy

Use of Enhanced Recovery After Surgery (ERAS) in Minimizing Opioid Use for Patients Undergoing Thyroidectomy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03988075

Enrollment

100

Registered

2019-06-17

Start date

2018-07-24

Completion date

2019-09-30

Last updated

2020-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Thyroidectomy

Brief summary

Pain control modalities were evaluated after thyroidectomy.

Detailed description

Pain control modalities were evaluated after thyroidectomy. Patients were randomized to one of two pain control regimens. The control group received conventional opioid based post operative analgesia while the test group received an enhanced recovery after surgery (ERAS) based anesthesia with use of acetaminophen and non-steroidal anti-inflammatory drugs for the post operative period with opioid medications available for break through pain only. Pain scores (measured on visual analog scale) and opioid use (measured in morphine equivalent dose) were measured after completion of the operation.

Interventions

OTHERAcetaminophen and hydrocodone based pain control

Patients receive acetaminophen 650mg every 4 for pain level 1-3, hydrocodone/acetaminophen 5/325mg every 4 for pain level 4-6, or hydrocodone/acetaminophen 10/650mg every 4 for pain level 7-10 on as needed basis.

OTHERAcetaminophen and ibuprofen based pain control

Patients receive standing dose of acetaminophen 650mg every 8 hours and ibuprofen 800mg every 8 hours with alternating ibuprofen and acetaminophen every 4 hours.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

Randomized to one of two study groups

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* thyroid disease

Exclusion criteria

* currently on opioid pain medications * on opioid pain meds in last 30 days * cannot take non-opioid medications * require more extensive operation than thyroidectomy

Design outcomes

Primary

Measure	Time frame	Description
visual analog scale pain level	1 hour post operatively	Pain level from 0 (no pain) to 10 (worst pain imaginable).

Secondary

Measure	Time frame	Description
opioid use	with the first 24 hours post operatively	the dose of opioid received by the patient

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026