Cirrhotic Patients With Septic Shock

Cirrhotic Patients Admitted to the ICU With Septic Shock: Factors Predicting Short and Long-term Outcome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03987048

Enrollment

149

Registered

2019-06-14

Start date

2014-04-30

Completion date

2015-04-30

Last updated

2019-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cirrhosis, Septic Shock

Brief summary

Cirrhotic patients have a poor outcome in intensive care unit (ICU). Septic shock is a leading cause of ICU admission and death in this specific population. We performed a monocentric retrospective study; all cirrhotic patients admitted in the ICU with septic shock from 2002 to 2013 were included. The aim of the study was to identify prognostic factors for both short- and long-term mortality in these patients. Demographic, clinical and biological data, organ supports, and outcomes were collected. Univariate and multivariate analysis were carried out regarding both ICU and one-year mortality.

Interventions

OTHERMeasure of short- and long-term mortality and analysis of independent predictors of short- and long-term mortality.

Data were collected regarding medical background, medical condition and management, both at admission and during the ICU stay. These included demographics, clinical, biological and therapeutic data. Outcome at ICU discharge and at one year were also recorded.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* age 18 or older * diagnosis of cirrhosis * diagnosis of septic shock at ICU admission

Exclusion criteria

* prior liver transplantation

Design outcomes

Primary

Measure	Time frame	Description
Short-term outcome: analysis of independent predictors of ICU mortality rate.	Between ICU admission (from January 2002 to December 2013) and ICU discharge	The predictors assessed independently are the clinical data, site of infection, biological data, liver scoring systems, organ failure, organ support and simplified acute physiology score (SAPS II), expressed in percentage of patients. The mortality rate is expressed in percentage of patients.
Long-term outcome: analysis of independent predictors of one-year mortality rate.	At one year after ICU admission (from January 2002 to December 2013)	The predictors assessed independently are the independent predictors found to be related to the short-term mortality rate, expressed in percentage of patients. The mortality rate is expressed in percentage of patients.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026