Obesity
Conditions
Brief summary
This study evaluates the associations between exposure to air pollutants, green space, and the gut microbiome and metabolome.
Detailed description
A rapidly evolving field of study suggests a link between the gut microbiome and fecal metabolome with obesity. Recent studies show that environmental exposures, such as ambient air pollution (AAP) exposure can affect gut bacteria and modify risk for obesity. Additionally, proximity to green space has been shown to reduce exposure to air pollutants and increase gut microbial diversity. The investigator's preliminary work has shown that near-roadway air pollution exposure was positively correlated with gut microbial taxa that have been linked with obesity. These findings suggest that air pollution exposure may increase susceptibility to obesity through alterations in the composition and function of the gut microbiome. Despite this, no studies have systematically examined the impact of air pollutants and green space on the gut microbiome and metabolome among adolescents. The overall goal of this research is to determine whether exposure to air pollutants and/or green space affect the gut microbiome and metabolome in young adults residing in Denver, Colorado. This study will examine residential-based estimates of air pollution exposure and green space and also perform detailed gut microbial and metabolite profiling in 100 adolescent and young adults.
Interventions
None listed
Sponsors
University of Colorado, Boulder
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 25 Years
Inclusion criteria
* The participant population includes young adults (18-25 years of age) who live in Denver, Colorado.
Exclusion criteria
*
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gut Microbiome | Measured once at baseline visit date | 16S rRNA and Shotgun Sequencing |
| Fecal Metabolome | Measured once at baseline visit date | Targeted and/or Un-targeted Metabolomics |
| Body mass index (BMI) | Measured once at baseline visit date | Weight and height will be combined to report BMI in kg/m\^2 |
| Body Composition | Measured once at baseline visit date | Waist and hip measurements will be taken |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physical Activity | Measured once at baseline | International Physical Activity Questionnaire |
| Air Pollution | One year before baseline visit date | Modeled residential exposure to air pollution |
| Fasting Insulin | Measured once at baseline | Fasting insulin (uU/mL) |
| Fasting Glucose | Measured once at baseline | Fasting Glucose (mg/dl) |
| Green Space | One year before baseline visit date | Modeled residential exposure to green space |
| Serum Metabolome | Measured once at baseline visit date | Targeted and/or Un-targeted Metabolomics |
| Diet | Measured once at baseline | Automated Self-Administered 24-Hour (ASA24) |
Countries
United States
Outcome results
None listed