Placental Transfusion Methods and Stem Cells

The Effect of Placental Transfusion Methods on the Potentially Transfusion Levels of Endothelial Progenitor Cell and CD34+ Hematopoietic Stem Cell

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03983902

Enrollment

Registered

2019-06-12

Start date

2019-07-01

Completion date

2021-06-30

Last updated

2019-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Placental Transfusion, Stem Cells

Keywords

stem cell, newborn, endothelial progenitor cell, CD34+ hematopoietic stem cell, delayed cord clamping, umbilical cord milking, immediate cord clamping

Brief summary

To measure the levels of endothelial progenitor cells and CD34+ hematopoietic stem cells levels, and placental residual volume by delayed cord clamping, umbilical cord milking or immediate cord clamping in newborns at different gestational weeks.

Detailed description

Umbilical cord blood is a rich source of stem cells. Placental transfusion is the transfer of the placental blood to the baby until the cord clamped during the birth. Placental transfusion can be accomplished by delayed cord clamping or umbilical cord milking. One group will receive 2 minutes of delayed cord clamping, the second group will receive umbilical cord milking and the third group will receive immediate cord clamping. Following the cord clamping, the blood samples will be taken from the placental site of the umbilical cord to measure the stem cells from all subjects and placental residual volume will be measured. Delivery room conditions, hospitalization (if needed), short-term outcome during hospitalization, prematurity related morbidities (if baby is preterm) will be recorded.

Interventions

PROCEDUREDelayed cord clamping

Delayed cord clamping will occur for up to 2 minutes.

PROCEDUREUmbilical cord milking

Umbilical cord milking will occur milking of the 30 cm of the cord from placental site to baby, at a speed of 5 cm/second, 3 times in preterm newborns, 4 times in term newborns.

PROCEDUREImmediate cord clamping

Immediate cord clamping will occur in 20 seconds after birth.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Intervention model description

Parallel assignment

Eligibility

Sex/Gender

ALL

Age

No minimum to 3 Minutes

Healthy volunteers

Inclusion criteria

Born at 24 weeks to 42 weeks infants

Exclusion criteria

Without parental consent, known congenital anomalies

Design outcomes

Primary

Measure	Time frame	Description
The levels of stem cells	18-months	Measurement of the levels of endothelial progenitor cells and CD34+ hematopoietic stem cells

Secondary

Measure	Time frame	Description
Placental residual volume	18-months	The placental residual volume by delayed cord clamping, umbilical cord milking or immediate cord clamping

Contacts

Primary ContactEmel Okulu, MD

emelokulu@gmail.com+90-312-595000

Backup ContactSaadet Arsan, MD

Saadet.Arsan@medicine.ankara.edu.tr+90-312-595000

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026