Laparoscopic Renal Surgery, Nerve Block, Pain Management
Conditions
Brief summary
This prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay，et al. between single-injection QLB(quadratus lumborum block)+ intravenous patient-controlled analgesia (IPCA) and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing laparoscopic partial nephrectomy.
Interventions
PROCEDUREsingle-injection TQLB(transmuscular quadratus lumborum block)
Inject 0.6ml/kg local anesthetics in between quadratus lumborum and psoas major under ultrasound guidance
PCIA was initiated using a pump set to deliver boluses of 1.5-2 mg of morphine with a 5-minute lockout interval and no background infusion. The maximal permitted dosage of morphine was set at 8 mg/h.
Sponsors
Cui Xulei
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
17 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-70 yrs * American Society of Anesthesiologists physical statusⅠ-Ⅲ * Undergo laparoscopic partial nephrectomy * Informed consent
Exclusion criteria
* A known allergy to the drugs being used * Coagulopathy, on anticoagulants * Analgesics intake, history of substance abuse * Participating in the investigation of another experimental agent * Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cumulative morphine consumption 8 hours after surgery | at the 8 hours after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cumulative morphine consumption at other time points after surgery | at 0, 2, 4, 12, 24 and 48 hours after surgery | — |
| The pain scores(at rest or on activity) determined by the numeric rating scale (NRS, 0-10) | at 0, 2, 4, 8,12, 24, 48 and 72 hours after surgery | NRS is an internationally recognized pain scale with 11 points ranging from 0 to 10 points, with 0 defined as no pain and 10 defined as the worst pain imaginable. |
| episodes of nausea and vomiting | within 24 hours after the surgery | — |
| patient satisfaction with anesthesia | at 48 hours after surgery | Patient satisfaction with anesthesia was assessed using a 5-point scale (5: very satisfied; 4: satisfied; 3: neither satisfied nor dissatisfied; 2: dissatisfied; 1: very dissatisfied) |
| time of recovery of bowl movement | within the 5 days after surgery | time from the end of the surgery to the first time of bowl movement |
| quality of recovery evaluated by the self-assessment 15-item quality of recovery (QoR) scale | at 72 hours and 120 hours after the sugery | QoR is a 15-item questionnaire which will score on a scale of 0-10 pertaining to patient's comfort, support system, pain, well-being, and ability to carry out daily activities, where 0 indicates none of the time and 10 indicates all of the time |
| postoperative length of hospital stay | within 2 weeks after the surgery | time to patient's discharge |
| ambulation time | within the 5 days after surgery | time from the end of the surgery to the first time to out-of-bed activity |
Countries
China
Outcome results
None listed