Sleep Deprivation
Conditions
Brief summary
The study is a case-controlled observational trial. Forty patients will be divided into 2 groups (good or poor sleepers) depending on their first postoperative night Bispectral index data. Firstly, this study aims to characterise the lung microbiota in patients treated with thyroid surgery. Secondly, it aims to evaluate microbiota and its influence on plasma kynurenine.
Detailed description
The study is a case-controlled observational trial. Forty patients will be divided into 2 groups (good or poor sleepers) depending on their first postoperative night Bispectral index data. Firstly, this study aims to characterise the lung microbiota in patients treated with thyroid surgery. Secondly, it aims to evaluate microbiota and its influence on plasma kynurenine.
Interventions
DRUGGeneral anesthesia
For maintenance of propofol anesthesia, total intravenous anesthesia was administered by using propofol (Fresenius Kabi, Austria GmbH) at a plasma target concentration (Marsh pharmacokinetic model software) of 2.5-4 μg/ml. Remifentanil (0.2-0.5 μg/kg/min) was given to all patients during the operation.
Sponsors
China Medical University, China
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* ethnic Chinese; * age, 18 to 65 years old; * American Society of Anaesthesiologists (ASA) physical status I or II
Exclusion criteria
* Cognitive difficulties * Affiliated with the Social Security System * Partial or complete gastrectomy * Previous esophageal surgery * Inability to conform to the study's requirements * Deprivation of a right to decide by an administrative or juridical entity * Ongoing participation or participation in another study \<1 month ago
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| gut microbiota | the first postoperative night | this study will characterise the gut microbiota in 2 groups of 30 patients. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bispectral index data | the first postoperative night | this study will characterise the Bispectral index data in 2 groups of 30 patients |
| plasma kynurenine concentrations | baseline and the first postoperative night | this study will characterise the plasma kynurenine concentrations in 2 groups of 30 patients |
Countries
China
Outcome results
None listed