Ovarian Cancer
Conditions
Keywords
surgery, cancer, ovarian, advanced
Brief summary
To demonstrate that ultra-radical surgery with multiple visceral resections and high tumor burden prior to surgery independently reduces the survival of patients with advanced ovarian cancer treated with complete cytoreductive surgery.
Detailed description
Primary objective : To demonstrate that ultra-radical surgery with multiple visceral resections and high tumor burden prior to surgery independently reduces the survival of patients with advanced ovarian cancer treated with complete cytoreductive surgery. Secondary objectives: 1. Demonstrate that, in patients with advanced ovarian cancer (FIGO stage IIIC-IVB) treated by complete cytoreduction surgery, the high tumor load before surgery decreases survival. / Evaluate whether there is a sub-group of patients at risk for whom the high tumor burden prior to surgery reduces survival. 2. Demonstrate that, in patients with advanced ovarian cancer (FIGO stage IIIC-IVB) treated by complete cytoreduction surgery, the extension of carcinomatosis to the upper abdomen reduces the chances of survival. / Assess whether there is a subgroup of patients at risk for whom the extension of carcinomatosis to the upper abdomen reduces survival. 3. Demonstrate that, in patients with advanced ovarian cancer (FIGO Stage IIIC-IVB) treated by complete cytoreduction surgery, invasion of the celiac lymph nodes reduces survival rates. / Assess whether there is a subset of patients at risk where the invasion of the celiac lymph nodes reduces survival. 4. Demonstrate that, in patients with advanced ovarian cancer (FIGO stage IIIC-IVB) treated with complete cytoreduction surgery, combination with surgical procedures reduces survival. / Evaluate whether there is a sub-group of at-risk patients for whom the combination of surgical procedures with ultra-radical surgery reduces survival.
Interventions
None listed
Sponsors
Institut Bergonié
Institut Paoli-Calmettes
Institut du Cancer de Montpellier - Val d'Aurelle
Hospital Universitario La Paz
Hospital Vall d'Hebron
Institut Claudius Regaud
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* confirmed histological diagnosis of ovarian epithelial cancer * complete cytoreduction surgery
Exclusion criteria
* women under 18 years or presence of residual tumor \>2.5mm after surgery or lack of data on performed surgical procedures or surgery performed before 2008, January or after 2015, Decembrer.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Patient survival | 4 years | patient survival after surgery (patient record) |
| Evaluation of the tumor burden | 1 day | Measurement of tumor size before surgery (patient record) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of the extension of carcinomatosis | 1 day | Number of tumor nodules before surgery (patient record) |
| Evaluation of the invasion of celiac lymph nodes | 1 day | Number of celiac lymph nodes before surgery (patient record) |
| Combination of surgical procedures | 1 day | Number and type of combination of surgical procedures (patient record) |
Countries
France
Outcome results
None listed