Heparin-induced Thrombocytopenia
Conditions
Brief summary
Thrombocytopenia is a frequent and serious adverse event in patients treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock. Similarly to postcardiac surgery patients, heparin-induced thrombocytopenia (HIT) could represent the causative underlying mechanism. However, the epidemiology as well as related mortality regarding HIT and VA-ECMO remains largely unknown. The investigators aimed to define the prevalence and associated 90-day mortality of HIT diagnosed under VA-ECMO.This retrospective study included patients under VA-ECMO from 20 French centers between 2012 and 2016.
Interventions
OTHERHospitalization for more than 3 days with high clinical suspicion of HIT and positive anti-PF4/heparin antibodies
Patients are classified according to results of functional tests as having either Confirmed or Excluded HIT.
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * Patient hospitalized in intensive care for a cardiovascular failure requiring the setting up of an ECMO-VA * ECMO-VA duration ≥ 3 days * HIT confirmed by immunological tests * Patient affiliated to a Social Security scheme
Exclusion criteria
* Known antecedent of TIH prior to cannulation * Pregnant woman * ECMO-VA following cardiopulmonary arrest or septic shock
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death | 90 days after inclusion |
Outcome results
None listed