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Effect of Emotion Mindsets on Emotion Processing

Effect of Emotion Mindsets on Emotion Processing: A Multilevel Experimental Investigation

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03978871
Enrollment
163
Registered
2019-06-07
Start date
2018-08-27
Completion date
2022-10-31
Last updated
2026-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emotions

Keywords

Brain, Functional Neuroimaging, Stress, Psychological, Emotions, Psychology, Developmental

Brief summary

The guiding scientific premise for this research is that a growth emotion mindset will promote more adaptive emotion processing than a fixed emotion mindset. Because emotional sensitivity is particularly salient in adolescent girls, we will focus on this group. Using an experimental design, adolescent girls will be randomly assigned to either a mindset manipulation or a control group (brain education). Each group will complete a 25-minute computer-based lesson followed by a social stressor and a functional magnetic resonance imaging session. Two specific aims will be addressed: (1) to determine whether a growth mindset induction, relative to a control condition, predicts more adaptive emotion processing at the neural, behavioral, and psychological levels of processing; and (2) to determine whether neural processing of emotion accounts for the effect of a growth emotion mindset manipulation on behavioral and psychological processing of emotion. This study builds on a strong empirical database establishing the effect of mindsets on multiple domains of functioning but will be the first to examine the implications of a growth vs. fixed mindset about emotion for emotion processing in adolescent girls, thereby elucidating one specific youth attribute that can support or disrupt emotional development.

Detailed description

150 adolescent girls will complete baseline measures and then be randomly assigned to one of two conditions and will complete a computer-based lesson (see below). Girls will then engage in a social stressor outside of the scanner as well as an emotional challenge and cognitive control task in the scanner and will complete post-scan measures. Two and four months after the scan session they will complete additional survey measures. Experimental condition: The (Growth Emotion Mindset) GEM manipulation, involves 6 components: (1) Introduction: discussion of emotional experiences in teenagers; (2) Explanation of neuroplasticity, emphasizing the potential for changes in the brain and modification of emotions during adolescence; (3) Scientific evidence for the effect of emotion regulation training on mood improvement; (4) Brief factual quizzes and written summary of key points; (5) Scenarios in which older youth describe challenging situations when they used growth mindsets to help regulate negative emotions; and (6) Self-persuasion exercise: a. Girls read a hypothetical scenario about an emotional challenge and describe their likely thoughts and feelings; b. Girls imagine the same event happening to another (younger) teen and help them understand how they can change, integrating what they learned about malleability of the brain and emotion. Control condition: The control condition involves a structurally similar session, with the same number and type of reading and writing activities, that focuses on general education about the brain. Social stressor. Using an adapted version of the Trier Social Stressor Test, girls will prepare a speech in which they convince a group of peers (who ostensibly will watch a video of the speech; in reality, there are no peers) that they should be selected for a fictional television show about teens' ability to form friendships. Girls face a computer screen displaying their image while preparing and presenting a speech. At intervals of 20 seconds, a female evaluator will mark a clipboard. Before and after the Trier, girls will rate several dimensions of state negative affect. After the Trier, girls will rate their use of in vivo emotion regulation strategies. Girls will then undergo scanner training and watch a neutral video during an anatomical scan. Emotional challenge (Social Evaluation Task). Girls will watch validated videos created for functional magnetic resonance imaging, which depict females making one of three types of statements with matching affective expression: negative social-evaluative, positive social-evaluative, or neutral. Before each video, girls will receive a prompt instructing them to imagine how they would feel if the female were a friend and if the statement was directed either toward the participant (immerse), or toward a stranger (reframe). After the cue, there will be a pause, presentation of the video, and another pause. After each trial, the participant will rate how bad they feel on a 5-point scale. Resting state. Following the emotional challenge, girls will remain still and fixate on a central cross. Greater ability to flexibly engage and disengage emotion regulation in response to changing external challenges (imposed by negative, positive, and neutral videos) is expected to be reflected in the functional connectome for minutes beyond the emotional challenge task, resulting in more within-network connectivity in cognitive control networks as well as increased connectivity with emotion regions in girls engaged in proactive emotion regulation. Emotional go-nogo. This task combines a cognitive control task (go-nogo) with emotion distractors depicting negative (social rejection), positive (social acceptance), or neutral (scrambled) images taken from a validated set of stimuli. Letters are presented sequentially in a small box at the center of the screen, with emotion distractors in the background. The distractors are presented alone , prior to presentation of the letter, to make it difficult to ignore the emotional content. Girls are instructed to ignore the images and respond as quickly as possible without sacrificing accuracy with a button press to every letter (go trials), except for Xs (no-go; 25 percent of trials). Girls acquire a prepotent tendency to press and must inhibit their responses during X trials. Edited June 2020: Anticipated 75% and 100% enrollment dates as well as primary and final study completion dates and primary endpoint analyses and reporting of results were changed due to recruitment and data collection obstacles posed by the coronavirus pandemic. The new dates were estimated based on the assumption that some recruitment and data collection will resume in the fall of 2020. If this is not possible or if families are reluctant to complete sessions, completion dates may need to be changed again at a later date. Edited November 2021: Although the 75% enrollment was reached, anticipated 100% enrollment date as well as primary and final study completion dates and primary endpoint analyses and reporting of results were changed due to ongoing recruitment and data collection obstacles posed by the coronavirus pandemic. Although a small amount of recruitment and data collection resumed fall of 2020-fall of 2021, obstacles still remain due to school and family reluctance to participate in research.

Interventions

BEHAVIORALGrowth Mindset

Growth emotion mindset induction

BEHAVIORALBrain Education

Brain education

Sponsors

University of Illinois at Urbana-Champaign
Lead SponsorOTHER
Auburn University
CollaboratorOTHER
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
CollaboratorNIH

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
FEMALE
Age
13 Years to 18 Years
Healthy volunteers
No

Inclusion criteria

* Female age 13-18 years old * Over-sample (approximately 1/3 of sample) for score \>= .75 standard deviation (SD) on a screening measure of fixed mindset about emotion * English-speaking * Ability to independently complete tasks and measures

Exclusion criteria

* History of surgery involving metal implants * Possible metal fragments in the eyes or other parts of body * Pacemaker * A history of claustrophobia * Braces * Weighing over 250 pounds * Pregnancy or possibility of being pregnant * Severe medical conditions (e.g., blind or deaf, head trauma) * Learning disability or other condition that interferes with ability to complete tasks

Design outcomes

Primary

MeasureTime frameDescription
Mean Change From Pre to Post Mindset Manipulation on Emotion Mindset Scale (Measures Beliefs About Whether Emotions Are Fixed or Malleable)Pre vs. Post Mindset Manipulation: baselineParticipants completed a six-item fixed emotion mindset measure (EMS-fixed) measure, prior to (pre-induction EMS) and following the induction lessons (post-induction EMS). Items were drawn from the Implicit Theories of Emotion Scale (Tamir et al., 2007) and the Emotion Mindset Scale (EMS; Livingstone, 2013). Participants rated each item on a 6-point scale (1 = Strongly Disagree to 6 =Strongly Agree). Means were computed for these items, with higher scores representing a higher fixed emotion mindset mindset. For this analysis, we compared mean change scores across the two conditions (mindset and control). Minimum=1 Maximum=6 High= more fixed emotion mindset, worse outcome
Mean Change From Pre to Post Mindset Manipulation on Emotional Self-efficacy Scale (Measure Beliefs About Ability to Control Emotions)Pre vs. Post Mindset Manipulation: baselineParticipants completed a measure assessing their perceived ability to manage emotions prior to and following the induction. Items were derived from the using and managing your own emotions subscale of the Youth-Emotional Self-efficacy Scale (5 items; Qualter et al., 2015). Participants rated the items on a 5-point Likert scale (1 = Disagree Strongly to 5 = Agree Strongly). Scores were computed as the mean of the items, with higher scores indicating greater emotion regulation self-efficacy. Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=5 High=better outcome
Mean Change From Pre to Post Mindset Manipulation on Emotional Self-efficacy Vignettes (Measure Beliefs About Ability to Control Emotions in Specific Situations)Pre vs. Post Mindset Manipulation: baselineTo assess emotion regulation self-efficacy participants completed a self-efficacy measure adapted from Tamir and colleagues (2007). Prior to and following the induction, participants were asked to rate 12 emotion-eliciting events drawn from daily life. Three scenarios were adapted from the Tamir self-efficacy measure (Tamir et al. 2007. Participants rated how confident they were in their ability to control their emotions in each scenario on a 5-point scale (1 = Not at All to 5 = Very Much). Scores were computed as the mean of the items, with higher scores reflecting greater self-efficacy. Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=5 High=better outcome
Mean Difference in Performance on Go/Nogo Task- Reaction TimePost Mindset Manipulation: baselineThe socioemotional Go/No-go presents participants with a socially appetitive image, socially aversive image, or neutral image. After the image, a white box with a black letter was superimposed on the image for 500 ms. Participants were instructed to respond as quickly as possible to every letter. Responses during these 500 ms were used for analysis. Mean reaction times (RT) in milliseconds to positive stimuli (pos.correctgoRT), negative stimuli (neg.correctgoRT) and neutral stimuli (neu.correctgoRT) were calculated, with higher numbers indicating slower RT. Will compare mean performance as reflected in reaction time across the two conditions (mindset and control)
Mean Difference in Performance on Go/Nogo Task- AccuracyPost Mindset Manipulation: baselineThe socioemotional Go/No-go presents participants with a socially appetitive image, socially aversive image, or neutral image. After, a letter was superimposed on the image. Participants were instructed to respond to every letter except for 'X'. Participants completed 4 blocks of each condition. Accurate responses to the letters after the socially appetitive images (positive accuracy), socially aversive image (negative accuracy) and neutral image (neutral accuracy) were indicated (0-1 scale). Mean scores across the four blocks were calculated, with higher scores indicating more accuracy. Will compare mean performance as reflected in accuracy across the two conditions (mindset and control)
Mean Difference in Emotion Regulation Strategies on the Emotion Regulation Strategy ScalePost Mindset Manipulation: baselineParticipants completed a measure to assess the emotion regulation strategies (ERS) they used during the Trier Social Stress Test (TSST). Items were rated on a 5-point scale (1 = Not at All to 5 = Very Much). Factor analyses yielded three emotion regulation strategies factors- involuntary dysregulation, proactive engagement, and cognitive avoidance. Scores were computed as the mean of the items on each factor (1 = Not at All to 5 = Very Much), with higher scores reflecting higher levels of each type of response. In analyses, we compare mean scores for each of these factors across the two conditions (mindset and control). Higher scores on proactive engagement are considered adaptive and higher scores on involuntary dysregulation and cognitive avoidance are considered maladaptive.
Mean Difference in Parameter Estimates of BOLD Signal for Amygdala Activation- Social Evaluation TaskPost Mindset Manipulation: baselineThe Social Evaluation Task (SET) examines emotion reactivity and regulation with social stimuli. Stimuli consisted of video clips with actors expressing criticism (negative condition), praise (positive condition) or neutral statements (neutral condition). Participants were asked to imagine the person was either an actor practicing lines (reframe condition), or a close friend (immerse condition). Participants were subsequently asked to rate how they felt on a 5 item Likert scale from "Very Good" to "Very Bad". To reduce the influence of carryover effects across blocks, participants also engaged in a counting task at the conclusion of each block. We conducted ROI analyses of bilateral amygdalae to compare activation patterns during relevant trials of the Social Evaluation Task (negative immerse \> neutral immerse) across experimental conditions (mindset vs control).
Mean Difference in Parameter Estimates of BOLD Signal for Amygdala Activation- Go/No-go TaskPost Mindset Manipulation: baselineThe Socioemotional Go/No-go Task examines inhibitory control in the presence of socioemotional distractors. Participants were presented with a socially aversive image, or neutral image for 300ms. After the image, a white box with a black letter was superimposed on the image for 500 ms. Participants were instructed to respond quickly to every letter except an infrequent nontarget letter. We conducted ROI analyses of bilateral amygdalae to compare activation patterns of emotion reactivity during relevant trials of the Socioemotional Go/No-go Task (negative \> neutral) across experimental conditions (mindset vs control).
Mean Difference in Parameter Estimates of BOLD Signal for Frontal Parietal Network-Amygdala Connectivity- Social Evaluation TaskPost Mindset Manipulation: baselineThe Social Evaluation Task (SET) examines emotion reactivity and regulation with social stimuli. Stimuli consisted of video clips with actors expressing criticism (negative condition), praise (positive condition) or neutral statements (neutral condition). Participants were asked to imagine the person was either an actor practicing lines (reframe condition), or a close friend (immerse condition). Participants were subsequently asked to rate how they felt on a 5 item Likert scale from "Very Good" to "Very Bad". To reduce the influence of carryover effects across blocks, participants also engaged in a counting task at the conclusion of each block. Psychophysiological interaction (PPI) analysis was conducted in SPM12 to examine task-dependent changes in connectivity between amygdalae and frontoparietal network (FPN) during relevant trials (negative reframe \> negative immerse) across experimental conditions (mindset vs control).
Mean Difference in Parameter Estimates of BOLD Signal for Frontal Parietal Network-Amygdala Connectivity- Go/No-go TaskPost Mindset Manipulation: baselineThe Socioemotional Go/No-go Task examines inhibitory control in the presence of socioemotional distractors. Participants were presented with a socially aversive image, or neutral image for 300ms. After the image, a white box with a black letter was superimposed on the image for 500 ms. Participants were instructed to respond quickly to every letter except an infrequent nontarget letter. Psychophysiological interaction (PPI) analysis was conducted in SPM12 to examine task-dependent changes in connectivity between amygdalae and frontoparietal network (FPN) during relevant trials of the Socioemotional Go/No-go Task (negative \> neutral) across experimental conditions (mindset vs control).
Mean Change on Self-Reported State Negative AffectPre-Trier vs. Post-Trier: baselineBefore (Pre-trier negative affect) and after (Post-trier negative affect) completing the Trier Social Stress Test (TSST) at baseline, participants completed ratings of negative emotions (10 items), modified from another affect measure (Owens et al., 2019), to test the efficacy of the TSST. Participants rated their emotions on a 100-point scale (0 = Not at All to 100 = Extremely) to indicate the extent they were feeling a negative emotion at that particular moment. Scores were computed as the mean of the items, with higher scores reflecting higher levels of negative emotions. In this analysis, we compared mean change scores across the two conditions (mindset and control).
Mean Difference on Self-Reported Affect on Social Evaluation TaskPost Mindset Manipulation: baselineThe Social Evaluation Task examines emotion reactivity and regulation in the context of social stimuli. Stimuli consisted of video clips with actors expressing criticism (negative immerse or reframe), praise (positive immerse or reframe), or neutral statements (neutral immerse). In immerse trials, participants imagined that the person was a close friend. During the reframe trials, participants imagined that the person was an actor. After each trial, participants rated how they felt from 1 (Very Good) to 5 (Very Bad). Means of each condition were computed with higher scores indicating more negative emotions. In this analysis, we compared mean difference between criticism and praise vs. neutral trials across the two conditions (mindset and control) for the Social Evaluation Task

Secondary

MeasureTime frameDescription
Mean Change From Baseline to 2 Months in Emotion Mindset Scale ScoresAt baseline and in approximately 2 monthsParticipants completed a six-item fixed emotion mindset measure (EMS-fixed) measure, prior to (pre-induction EMS) the induction lessons and again at at 2-month follow-up. Items were drawn from the Implicit Theories of Emotion Scale (Tamir et al., 2007) and the Emotion Mindset Scale (EMS; Livingstone, 2013). Participants rated each item on a 6-point scale (1 = Strongly Disagree to 6 =Strongly Agree). Means were computed for these items, with higher scores representing a higher fixed emotion mindset mindset. Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=6 High=better outcome
Mean Change From Baseline to 4 Months in Emotion Mindset ScoresAt baseline and in approximately 4 monthsParticipants completed a six-item fixed emotion mindset measure (EMS-fixed) measure, prior to (pre-induction EMS) the induction lessons and again at at 4-month follow-up. Items were drawn from the Implicit Theories of Emotion Scale (Tamir et al., 2007) and the Emotion Mindset Scale (EMS; Livingstone, 2013). Participants rated each item on a 6-point scale (1 = Strongly Disagree to 6 =Strongly Agree). Means were computed for these items, with higher scores representing a higher fixed emotion mindset mindset. Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=6 High=better outcome
Mean Change From Baseline to 2 Months in Emotional Self-efficacy Scale Scores (Measure Beliefs About Ability to Control Emotions)At baseline and in approximately 2 monthsParticipants completed a measure assessing their perceived ability to manage emotions prior to the induction and again at a 2-month follow-up. Items were derived from the using and managing your own emotions subscale of the Youth-Emotional Self-efficacy Scale (5 items; Qualter et al., 2015). Participants rated the items on a 5-point Likert scale (1 = Disagree Strongly to 5 = Agree Strongly). Scores were computed as the mean of the items, with higher scores indicating greater emotion regulation self-efficacy. Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=5 High=better outcome.
Mean Change From Baseline to 4 Months in Emotional Self-efficacy Scale Scores (Measure Beliefs About Ability to Control Emotions)At baseline and in approximately 4 monthsParticipants completed a measure assessing their perceived ability to manage emotions prior to the induction and again at a 4-month follow-up. Items were derived from the using and managing your own emotions subscale of the Youth-Emotional Self-efficacy Scale (5 items; Qualter et al., 2015). Participants rated the items on a 5-point Likert scale (1 = Disagree Strongly to 5 = Agree Strongly). Scores were computed as the mean of the items, with higher scores indicating greater emotion regulation self-efficacy. Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=5 High=better outcome.
Mean Change From Baseline to 2 Months in Emotional Self-efficacy Vignettes ScoresAt baseline and in approximately 2 monthsTo assess emotion regulation self-efficacy participants completed a self-efficacy measure adapted from Tamir and colleagues (2007). Prior to the induction and again. at a 2-month follow-up, participants were asked to rate 12 emotion-eliciting events drawn from daily life. Three scenarios were adapted from the Tamir self-efficacy measure (Tamir et al. 2007. Participants rated how confident they were in their ability to control their emotions in each scenario on a 5-point scale (1 = Not at All to 5 = Very Much). Scores were computed as the mean of the items, with higher scores reflecting greater self-efficacy.Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=5 High=better outcome
Mean Change From Baseline to 4 Months in Emotional Self-efficacy Vignettes ScoresAt baseline and in approximately 4 monthsTo assess emotion regulation self-efficacy participants completed a self-efficacy measure adapted from Tamir and colleagues (2007). Prior to the induction and again at a 4-month follow-up, participants were asked to rate 12 emotion-eliciting events drawn from daily life. Three scenarios were adapted from the Tamir self-efficacy measure (Tamir et al. 2007. Participants rated how confident they were in their ability to control their emotions in each scenario on a 5-point scale (1 = Not at All to 5 = Very Much). Scores were computed as the mean of the items, with higher scores reflecting greater self-efficacy.Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=5 High=better outcome
Mean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresAt baseline and in approximately 2 monthsTo assess emotion (dys)regulation, participants completed a novel 44-item emotion regulation measure at baseline and again at a 2-month follow-up. Items were rated on a 5-point scale (1 = Not at All to 5 = Very Much). Factor analyses yielded three emotion regulation strategies factors- proactive engagement, involuntary dysregulation, and disengagement. Scores were computed as the mean of the items on each factor (1 = Not at All to 5 = Very Much), with higher scores reflecting higher levels of type of response. Higher scores on proactive engagement are considered adaptive and higher scores on involuntary dysregulation are maladaptive. Will compare mean change scores across the two conditions (mindset and control)
Mean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresAt baseline and in approximately 4 monthsTo assess emotion (dys)regulation, participants completed a novel 44-item emotion regulation measure at baseline and again at a 4-month follow-up. Items were rated on a 5-point scale (1 = Not at All to 5 = Very Much). Factor analyses yielded three emotion regulation strategies factors- proactive engagement, involuntary dysregulation, and disengagement. Scores were computed as the mean of the items on each factor (1 = Not at All to 5 = Very Much), with higher scores reflecting higher levels of type of response. Higher scores on proactive engagement are considered adaptive and higher scores on involuntary dysregulation are maladaptive. Will compare mean change scores across the two conditions (mindset and control) Will compare mean change scores across the two conditions (mindset and control)

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORKaren D Rudolph, PhD

University of Illinois, Urbana Champaign

Participant flow

Recruitment details

Participants were recruited from local high schools between August of 2018 and June of 2022. The first participant was enrolled in the main study in August of 2018 and the last participant was enrolled in June of 2022. The study was completed by October of 2022.

Pre-assignment details

One additional participant consented, but then declined participation due to concerns about claustrophobia while in the fMRI machine.

Participants by arm

ArmCount
Growth Mindset
Persuasive education about emotions, brain development, and teenagers' ability to learn how to manage emotions Growth Mindset: Growth emotion mindset induction
81
Brain Education
Neutral education about functions of different parts of the brain Control: Brain education
82
Total163

Baseline characteristics

CharacteristicTotalBrain EducationGrowth Mindset
Affect Scale
mean Negative Affect post trier (mt1posttrierneg)
15.78 score on a scale
STANDARD_DEVIATION 14.56
16.51 score on a scale
STANDARD_DEVIATION 14.35
15.05 score on a scale
STANDARD_DEVIATION 14.83
Affect Scale
mean Negative Affect pre trier (mt1pretrierneg)
7.55 score on a scale
STANDARD_DEVIATION 9.12
7.90 score on a scale
STANDARD_DEVIATION 8.57
7.21 score on a scale
STANDARD_DEVIATION 9.68
Age, Categorical
<=18 years
163 Participants82 Participants81 Participants
Age, Categorical
>=65 years
0 Participants0 Participants0 Participants
Age, Categorical
Between 18 and 65 years
0 Participants0 Participants0 Participants
Age, Continuous15.68 years
STANDARD_DEVIATION 1.08
15.72 years
STANDARD_DEVIATION 1.06
15.63 years
STANDARD_DEVIATION 1.1
Caregiver 1 Relationship to Child
Biological Father
18 Participants9 Participants9 Participants
Caregiver 1 Relationship to Child
Biological Mother
139 Participants70 Participants69 Participants
Caregiver 1 Relationship to Child
Missing
1 Participants1 Participants0 Participants
Caregiver 1 Relationship to Child
Other
3 Participants1 Participants2 Participants
Caregiver 1 Relationship to Child
Stepmother
2 Participants1 Participants1 Participants
Caregiver 2 Relationship to Child
Biological Father
108 Participants53 Participants55 Participants
Caregiver 2 Relationship to Child
Biological Mother
18 Participants10 Participants8 Participants
Caregiver 2 Relationship to Child
Missing
27 Participants14 Participants13 Participants
Caregiver 2 Relationship to Child
Other
4 Participants1 Participants3 Participants
Caregiver 2 Relationship to Child
Stepfather
5 Participants3 Participants2 Participants
Caregiver 2 Relationship to Child
Stepmother
1 Participants1 Participants0 Participants
Emotion Mindset Scale (Post-Induction EMS)2.46 score on a scale
STANDARD_DEVIATION 0.95
2.76 score on a scale
STANDARD_DEVIATION 0.9
2.17 score on a scale
STANDARD_DEVIATION 0.9
Emotion Mindset Scale (Pre-Induction EMS)3.03 score on a scale
STANDARD_DEVIATION 0.94
3.03 score on a scale
STANDARD_DEVIATION 0.92
3.03 score on a scale
STANDARD_DEVIATION 0.96
Emotion Regulation Self-Efficacy (Post-ESES)3.59 score on a scale
STANDARD_DEVIATION 0.86
3.40 score on a scale
STANDARD_DEVIATION 0.86
3.79 score on a scale
STANDARD_DEVIATION 0.82
Emotion Regulation Self-Efficacy (Pre-ESES)3.43 score on a scale
STANDARD_DEVIATION 0.84
3.34 score on a scale
STANDARD_DEVIATION 0.89
3.53 score on a scale
STANDARD_DEVIATION 0.79
Emotion Regulation Strategies (ERS)
Cognitive avoidance factor
2.70 score on a scale
STANDARD_DEVIATION 1.01
2.63 score on a scale
STANDARD_DEVIATION 1
2.77 score on a scale
STANDARD_DEVIATION 1.03
Emotion Regulation Strategies (ERS)
Involuntary dysregulation factor
2.65 score on a scale
STANDARD_DEVIATION 1.03
2.75 score on a scale
STANDARD_DEVIATION 1.05
2.54 score on a scale
STANDARD_DEVIATION 1.01
Emotion Regulation Strategies (ERS)
Proactive engagement factor
2.87 score on a scale
STANDARD_DEVIATION 1.02
2.71 score on a scale
STANDARD_DEVIATION 1.02
3.05 score on a scale
STANDARD_DEVIATION 1.01
Female Caregiver's Highest Level of Education
Associate's degree
11 Participants7 Participants4 Participants
Female Caregiver's Highest Level of Education
Bachelor's degree (B.A., B.S.)
45 Participants20 Participants25 Participants
Female Caregiver's Highest Level of Education
High school diploma
12 Participants4 Participants8 Participants
Female Caregiver's Highest Level of Education
Master's Degree (M.A., M.S.)
42 Participants23 Participants19 Participants
Female Caregiver's Highest Level of Education
Missing
2 Participants1 Participants1 Participants
Female Caregiver's Highest Level of Education
Professional Degree (M.D., PhD., etc.)
13 Participants6 Participants7 Participants
Female Caregiver's Highest Level of Education
Some college
25 Participants15 Participants10 Participants
Female Caregiver's Highest Level of Education
Some graduate school
12 Participants6 Participants6 Participants
Female Caregiver's Highest Level of Education
Some high school
1 Participants0 Participants1 Participants
Grade
Eighth Grade
16 Participants10 Participants6 Participants
Grade
Eleventh Grade
31 Participants17 Participants14 Participants
Grade
Ninth Grade
67 Participants29 Participants38 Participants
Grade
Tenth Grade
45 Participants25 Participants20 Participants
Grade
Twelfth Grade
4 Participants1 Participants3 Participants
Induction Validity Check
Easy to Understand (t1understand)
8.63 score on a scale
STANDARD_DEVIATION 1.77
8.22 score on a scale
STANDARD_DEVIATION 1.83
9.04 score on a scale
STANDARD_DEVIATION 1.62
Induction Validity Check
Informative (t1informative)
8.18 score on a scale
STANDARD_DEVIATION 1.75
8.01 score on a scale
STANDARD_DEVIATION 1.88
8.35 score on a scale
STANDARD_DEVIATION 1.61
Induction Validity Check
Interesting (t1interesting)
7.25 score on a scale
STANDARD_DEVIATION 1.93
7.05 score on a scale
STANDARD_DEVIATION 2.05
7.46 score on a scale
STANDARD_DEVIATION 1.79
Induction Validity Check
mean induction validity (mt1validity)
7.61 score on a scale
STANDARD_DEVIATION 1.49
7.21 score on a scale
STANDARD_DEVIATION 1.57
8.01 score on a scale
STANDARD_DEVIATION 1.3
Induction Validity Check
Persuasive (t1persuasive)
6.37 score on a scale
STANDARD_DEVIATION 2.43
5.55 score on a scale
STANDARD_DEVIATION 2.54
7.20 score on a scale
STANDARD_DEVIATION 2.02
Induction Validity Check
Validity Affect (t1validityaffect)
7.55 score on a scale
STANDARD_DEVIATION 1.7
7.23 score on a scale
STANDARD_DEVIATION 1.5
7.86 score on a scale
STANDARD_DEVIATION 1.83
Male Caregiver's Highest Level of Education
8th grade completed
1 Participants1 Participants0 Participants
Male Caregiver's Highest Level of Education
Associate's Degree
17 Participants9 Participants8 Participants
Male Caregiver's Highest Level of Education
Bachelor's Degree (B.A., B.S.)
34 Participants18 Participants16 Participants
Male Caregiver's Highest Level of Education
High school diploma
5 Participants0 Participants5 Participants
Male Caregiver's Highest Level of Education
Master's Degree (M.A., M.S.)
26 Participants11 Participants15 Participants
Male Caregiver's Highest Level of Education
Missing
25 Participants13 Participants12 Participants
Male Caregiver's Highest Level of Education
Professional Degree (M.D., PhD., etc.)
29 Participants17 Participants12 Participants
Male Caregiver's Highest Level of Education
Some college
22 Participants10 Participants12 Participants
Male Caregiver's Highest Level of Education
Some graduate school
3 Participants3 Participants0 Participants
Male Caregiver's Highest Level of Education
Some high school
1 Participants0 Participants1 Participants
Marital Status of Caregiver
Married
125 Participants63 Participants62 Participants
Marital Status of Caregiver
Other (specified)
3 Participants2 Participants1 Participants
Marital Status of Caregiver
Separated
2 Participants1 Participants1 Participants
Marital Status of Caregiver
Single (divorced)
19 Participants8 Participants11 Participants
Marital Status of Caregiver
Single (never married)
13 Participants7 Participants6 Participants
Race/Ethnicity, Customized
African American
17 participants10 participants7 participants
Race/Ethnicity, Customized
Asian
14 participants6 participants8 participants
Race/Ethnicity, Customized
Latina/o
7 participants3 participants4 participants
Race/Ethnicity, Customized
Other
17 participants7 participants10 participants
Race/Ethnicity, Customized
White
108 participants56 participants52 participants
Region of Enrollment
United States
163 participants82 participants81 participants
Revised Child Manifest Anxiety Scale (RCMAS)13.61 score on a scale
STANDARD_DEVIATION 6.14
13.61 score on a scale
STANDARD_DEVIATION 6.24
13.62 score on a scale
STANDARD_DEVIATION 6.08
Risk Group
High Risk
55 Participants28 Participants27 Participants
Risk Group
Low Risk
108 Participants54 Participants54 Participants
School Code
School 1
9 Participants6 Participants3 Participants
School Code
School 10
10 Participants7 Participants3 Participants
School Code
School 11
5 Participants4 Participants1 Participants
School Code
School 12
18 Participants6 Participants12 Participants
School Code
School 13
6 Participants1 Participants5 Participants
School Code
School 14
5 Participants3 Participants2 Participants
School Code
School 15
12 Participants7 Participants5 Participants
School Code
School 2
12 Participants5 Participants7 Participants
School Code
School 3
1 Participants0 Participants1 Participants
School Code
School 4
6 Participants2 Participants4 Participants
School Code
School 5
10 Participants8 Participants2 Participants
School Code
School 6
18 Participants2 Participants16 Participants
School Code
School 7
28 Participants21 Participants7 Participants
School Code
School 8
14 Participants2 Participants12 Participants
School Code
School 9
9 Participants8 Participants1 Participants
Sex: Female, Male
Female
163 Participants82 Participants81 Participants
Sex: Female, Male
Male
0 Participants0 Participants0 Participants
Short Mood and Feelings Questionnaire (SMFQ) Child1.82 score on a scale
STANDARD_DEVIATION 0.66
1.80 score on a scale
STANDARD_DEVIATION 0.64
1.84 score on a scale
STANDARD_DEVIATION 0.68
Social Evaluation (SET) Task
Mean Negative Immerse
4.31 units on a scale
STANDARD_DEVIATION 0.57
4.28 units on a scale
STANDARD_DEVIATION 0.63
4.34 units on a scale
STANDARD_DEVIATION 0.51
Social Evaluation (SET) Task
Mean Negative Reframe
3.48 units on a scale
STANDARD_DEVIATION 0.59
3.45 units on a scale
STANDARD_DEVIATION 0.67
3.49 units on a scale
STANDARD_DEVIATION 0.51
Social Evaluation (SET) Task
Mean Neutral Immerse
2.89 units on a scale
STANDARD_DEVIATION 0.38
2.87 units on a scale
STANDARD_DEVIATION 0.43
2.90 units on a scale
STANDARD_DEVIATION 0.33
Social Evaluation (SET) Task
Mean Positive Immerse
1.61 units on a scale
STANDARD_DEVIATION 0.59
1.61 units on a scale
STANDARD_DEVIATION 0.58
1.61 units on a scale
STANDARD_DEVIATION 0.6
Social Evaluation (SET) Task
Mean Positive Reframe
2.36 units on a scale
STANDARD_DEVIATION 0.62
2.32 units on a scale
STANDARD_DEVIATION 0.6
2.39 units on a scale
STANDARD_DEVIATION 0.64
Socioemotional Go/No-go Task- Accuracy
negative accuracy
0.63 score on a scale
STANDARD_DEVIATION 0.11
0.62 score on a scale
STANDARD_DEVIATION 0.12
0.64 score on a scale
STANDARD_DEVIATION 0.1
Socioemotional Go/No-go Task- Accuracy
neutral accuracy
0.64 score on a scale
STANDARD_DEVIATION 0.12
0.63 score on a scale
STANDARD_DEVIATION 0.13
0.65 score on a scale
STANDARD_DEVIATION 0.11
Socioemotional Go/No-go Task- Accuracy
Positive accuracy
0.62 score on a scale
STANDARD_DEVIATION 0.11
0.60 score on a scale
STANDARD_DEVIATION 0.12
0.63 score on a scale
STANDARD_DEVIATION 0.1
Socioemotional Go/No-go Task- Reaction Time
mean reaction time to correct go negative condition (neg.correctgoRT)
427.98 Reaction time in milliseconds
STANDARD_DEVIATION 34.2
431.78 Reaction time in milliseconds
STANDARD_DEVIATION 31.89
424.19 Reaction time in milliseconds
STANDARD_DEVIATION 36.18
Socioemotional Go/No-go Task- Reaction Time
mean reaction time to correct go neutral condition (neu.correctgoRT)
432.37 Reaction time in milliseconds
STANDARD_DEVIATION 30.63
434.35 Reaction time in milliseconds
STANDARD_DEVIATION 37.7
430.37 Reaction time in milliseconds
STANDARD_DEVIATION 33.42
Socioemotional Go/No-go Task- Reaction Time
mean reaction time to correct go positive condition (pos.correctgoRT)
430.66 Reaction time in milliseconds
STANDARD_DEVIATION 33.86
433.44 Reaction time in milliseconds
STANDARD_DEVIATION 28.81
427.89 Reaction time in milliseconds
STANDARD_DEVIATION 38.25
Tamir post self-efficacy2.94 score on a scale
STANDARD_DEVIATION 0.72
2.72 score on a scale
STANDARD_DEVIATION 0.7
3.16 score on a scale
STANDARD_DEVIATION 0.67
Tamir pre self-efficacy2.79 score on a scale
STANDARD_DEVIATION 0.63
2.70 score on a scale
STANDARD_DEVIATION 0.62
2.89 score on a scale
STANDARD_DEVIATION 0.62
Total Gross Annual Family Income
$0-14,999
2 Participants2 Participants0 Participants
Total Gross Annual Family Income
$15-29,999
8 Participants3 Participants5 Participants
Total Gross Annual Family Income
$30-44,999
14 Participants7 Participants7 Participants
Total Gross Annual Family Income
$45-59,999
23 Participants8 Participants15 Participants
Total Gross Annual Family Income
$60-74,999
15 Participants6 Participants9 Participants
Total Gross Annual Family Income
$75-89,999
9 Participants5 Participants4 Participants
Total Gross Annual Family Income
$90,000 and over
90 Participants50 Participants40 Participants
Total Gross Annual Family Income
Missing
2 Participants1 Participants1 Participants
Youth Emotion Regulation and Dysregulation Scale (YERD)
Disengagement Factor
3.13 score on a scale
STANDARD_DEVIATION 0.69
3.02 score on a scale
STANDARD_DEVIATION 0.73
3.23 score on a scale
STANDARD_DEVIATION 0.65
Youth Emotion Regulation and Dysregulation Scale (YERD)
Involuntary Dysregulation Factor
2.45 score on a scale
STANDARD_DEVIATION 0.71
2.47 score on a scale
STANDARD_DEVIATION 0.75
2.44 score on a scale
STANDARD_DEVIATION 0.66
Youth Emotion Regulation and Dysregulation Scale (YERD)
Proactive Engagement Factor
2.83 score on a scale
STANDARD_DEVIATION 0.78
2.70 score on a scale
STANDARD_DEVIATION 0.77
2.96 score on a scale
STANDARD_DEVIATION 0.77

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
deaths
Total, all-cause mortality
0 / 00 / 0
other
Total, other adverse events
0 / 00 / 0
serious
Total, serious adverse events
0 / 00 / 0

Outcome results

Primary

Mean Change From Pre to Post Mindset Manipulation on Emotional Self-efficacy Scale (Measure Beliefs About Ability to Control Emotions)

Participants completed a measure assessing their perceived ability to manage emotions prior to and following the induction. Items were derived from the using and managing your own emotions subscale of the Youth-Emotional Self-efficacy Scale (5 items; Qualter et al., 2015). Participants rated the items on a 5-point Likert scale (1 = Disagree Strongly to 5 = Agree Strongly). Scores were computed as the mean of the items, with higher scores indicating greater emotion regulation self-efficacy. Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=5 High=better outcome

Time frame: Pre vs. Post Mindset Manipulation: baseline

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Pre to Post Mindset Manipulation on Emotional Self-efficacy Scale (Measure Beliefs About Ability to Control Emotions)pre-Emotional Self-efficacy3.53 score on a scaleStandard Deviation 0.79
Growth MindsetMean Change From Pre to Post Mindset Manipulation on Emotional Self-efficacy Scale (Measure Beliefs About Ability to Control Emotions)post-Emotional Self-efficacy3.79 score on a scaleStandard Deviation 0.82
Brain EducationMean Change From Pre to Post Mindset Manipulation on Emotional Self-efficacy Scale (Measure Beliefs About Ability to Control Emotions)pre-Emotional Self-efficacy3.34 score on a scaleStandard Deviation 0.89
Brain EducationMean Change From Pre to Post Mindset Manipulation on Emotional Self-efficacy Scale (Measure Beliefs About Ability to Control Emotions)post-Emotional Self-efficacy3.40 score on a scaleStandard Deviation 0.86
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation). This is a test of between by within-subjects interaction effect.p-value: 0.023ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation). This is a test of between by within-subjects interaction effect. Clarity of the psycho-educational lessons was included as a covariate.p-value: 0.034ANCOVA
Primary

Mean Change From Pre to Post Mindset Manipulation on Emotional Self-efficacy Vignettes (Measure Beliefs About Ability to Control Emotions in Specific Situations)

To assess emotion regulation self-efficacy participants completed a self-efficacy measure adapted from Tamir and colleagues (2007). Prior to and following the induction, participants were asked to rate 12 emotion-eliciting events drawn from daily life. Three scenarios were adapted from the Tamir self-efficacy measure (Tamir et al. 2007. Participants rated how confident they were in their ability to control their emotions in each scenario on a 5-point scale (1 = Not at All to 5 = Very Much). Scores were computed as the mean of the items, with higher scores reflecting greater self-efficacy. Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=5 High=better outcome

Time frame: Pre vs. Post Mindset Manipulation: baseline

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Pre to Post Mindset Manipulation on Emotional Self-efficacy Vignettes (Measure Beliefs About Ability to Control Emotions in Specific Situations)pre-induction Emotional Self-Efficacy2.89 score on a scaleStandard Deviation 0.62
Growth MindsetMean Change From Pre to Post Mindset Manipulation on Emotional Self-efficacy Vignettes (Measure Beliefs About Ability to Control Emotions in Specific Situations)post-induction Emotional Self-Efficacy3.16 score on a scaleStandard Deviation 0.67
Brain EducationMean Change From Pre to Post Mindset Manipulation on Emotional Self-efficacy Vignettes (Measure Beliefs About Ability to Control Emotions in Specific Situations)pre-induction Emotional Self-Efficacy2.70 score on a scaleStandard Deviation 0.62
Brain EducationMean Change From Pre to Post Mindset Manipulation on Emotional Self-efficacy Vignettes (Measure Beliefs About Ability to Control Emotions in Specific Situations)post-induction Emotional Self-Efficacy2.72 score on a scaleStandard Deviation 0.7
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation). This is a test of between by within-subjects interaction effect.p-value: <0.001ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation). This is a test of between by within-subjects interaction effect. Clarity of the psycho-educational lessons was included as a covariate.p-value: 0.002ANCOVA
Primary

Mean Change From Pre to Post Mindset Manipulation on Emotion Mindset Scale (Measures Beliefs About Whether Emotions Are Fixed or Malleable)

Participants completed a six-item fixed emotion mindset measure (EMS-fixed) measure, prior to (pre-induction EMS) and following the induction lessons (post-induction EMS). Items were drawn from the Implicit Theories of Emotion Scale (Tamir et al., 2007) and the Emotion Mindset Scale (EMS; Livingstone, 2013). Participants rated each item on a 6-point scale (1 = Strongly Disagree to 6 =Strongly Agree). Means were computed for these items, with higher scores representing a higher fixed emotion mindset mindset. For this analysis, we compared mean change scores across the two conditions (mindset and control). Minimum=1 Maximum=6 High= more fixed emotion mindset, worse outcome

Time frame: Pre vs. Post Mindset Manipulation: baseline

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Pre to Post Mindset Manipulation on Emotion Mindset Scale (Measures Beliefs About Whether Emotions Are Fixed or Malleable)pre-induction EMS3.03 score on a scaleStandard Deviation 0.96
Growth MindsetMean Change From Pre to Post Mindset Manipulation on Emotion Mindset Scale (Measures Beliefs About Whether Emotions Are Fixed or Malleable)post-induction EMS2.17 score on a scaleStandard Deviation 0.9
Brain EducationMean Change From Pre to Post Mindset Manipulation on Emotion Mindset Scale (Measures Beliefs About Whether Emotions Are Fixed or Malleable)pre-induction EMS3.03 score on a scaleStandard Deviation 0.92
Brain EducationMean Change From Pre to Post Mindset Manipulation on Emotion Mindset Scale (Measures Beliefs About Whether Emotions Are Fixed or Malleable)post-induction EMS2.76 score on a scaleStandard Deviation 0.9
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation). This is a test of between by within-subjects interaction effect.p-value: <0.001ANOVA
Primary

Mean Change on Self-Reported State Negative Affect

Before (Pre-trier negative affect) and after (Post-trier negative affect) completing the Trier Social Stress Test (TSST) at baseline, participants completed ratings of negative emotions (10 items), modified from another affect measure (Owens et al., 2019), to test the efficacy of the TSST. Participants rated their emotions on a 100-point scale (0 = Not at All to 100 = Extremely) to indicate the extent they were feeling a negative emotion at that particular moment. Scores were computed as the mean of the items, with higher scores reflecting higher levels of negative emotions. In this analysis, we compared mean change scores across the two conditions (mindset and control).

Time frame: Pre-Trier vs. Post-Trier: baseline

Population: Six participants declined participation on this task.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change on Self-Reported State Negative AffectPre-trier negative affect6.93 score on a scaleStandard Deviation 9.66
Growth MindsetMean Change on Self-Reported State Negative AffectPost-trier negative affect15.05 score on a scaleStandard Deviation 14.83
Brain EducationMean Change on Self-Reported State Negative AffectPre-trier negative affect8.00 score on a scaleStandard Deviation 8.63
Brain EducationMean Change on Self-Reported State Negative AffectPost-trier negative affect16.51 score on a scaleStandard Deviation 14.35
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation). This is a test of between by within-subjects interaction effect.p-value: 0.833ANOVA
Primary

Mean Difference in Emotion Regulation Strategies on the Emotion Regulation Strategy Scale

Participants completed a measure to assess the emotion regulation strategies (ERS) they used during the Trier Social Stress Test (TSST). Items were rated on a 5-point scale (1 = Not at All to 5 = Very Much). Factor analyses yielded three emotion regulation strategies factors- involuntary dysregulation, proactive engagement, and cognitive avoidance. Scores were computed as the mean of the items on each factor (1 = Not at All to 5 = Very Much), with higher scores reflecting higher levels of each type of response. In analyses, we compare mean scores for each of these factors across the two conditions (mindset and control). Higher scores on proactive engagement are considered adaptive and higher scores on involuntary dysregulation and cognitive avoidance are considered maladaptive.

Time frame: Post Mindset Manipulation: baseline

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Difference in Emotion Regulation Strategies on the Emotion Regulation Strategy Scaleinvoluntary dysregulation2.54 units on a scaleStandard Deviation 1.01
Growth MindsetMean Difference in Emotion Regulation Strategies on the Emotion Regulation Strategy Scaleproactive engagement3.05 units on a scaleStandard Deviation 1.01
Growth MindsetMean Difference in Emotion Regulation Strategies on the Emotion Regulation Strategy Scalecognitive avoidance2.77 units on a scaleStandard Deviation 1.03
Brain EducationMean Difference in Emotion Regulation Strategies on the Emotion Regulation Strategy Scaleinvoluntary dysregulation2.75 units on a scaleStandard Deviation 1.05
Brain EducationMean Difference in Emotion Regulation Strategies on the Emotion Regulation Strategy Scaleproactive engagement2.71 units on a scaleStandard Deviation 1.02
Brain EducationMean Difference in Emotion Regulation Strategies on the Emotion Regulation Strategy Scalecognitive avoidance2.63 units on a scaleStandard Deviation 1
Comparison: We are reporting the p-value for the group effect (Growth Mindset vs. Brain Education) for the ERS emotion regulation involuntary dysregulation subscale post psycho-educational lesson. This is a test of between-subjects effect.p-value: 0.217ANOVA
Comparison: We are reporting the p-value for the group effect (Growth Mindset vs. Brain Education) for the ERS emotion regulation involuntary dysregulation subscale post psycho-educational lesson. This is a test of between-subjects effect. Clarity of the psycho-educational lessons was included as a covariate.p-value: 0.458ANCOVA
Comparison: We are reporting the p-value for the group effect (Growth Mindset vs. Brain Education) for the ERS emotion regulation proactive engagement subscale post psycho-educational lesson. This is a test of between-subjects effect.p-value: 0.037ANOVA
Comparison: We are reporting the p-value for the group effect (Growth Mindset vs. Brain Education) for the ERS emotion regulation proactive engagement subscale post psycho-educational lesson. This is a test of between-subjects effect. Clarity of the psycho-educational lessons was included as a covariate.p-value: 0.107ANCOVA
Comparison: We are reporting the p-value for the group effect (Growth Mindset vs. Brain Education) for the ERS emotion regulation cognitive avoidance subscale post psycho-educational lesson. This is a test of between-subjects test.p-value: 0.369ANOVA
Primary

Mean Difference in Parameter Estimates of BOLD Signal for Amygdala Activation- Go/No-go Task

The Socioemotional Go/No-go Task examines inhibitory control in the presence of socioemotional distractors. Participants were presented with a socially aversive image, or neutral image for 300ms. After the image, a white box with a black letter was superimposed on the image for 500 ms. Participants were instructed to respond quickly to every letter except an infrequent nontarget letter. We conducted ROI analyses of bilateral amygdalae to compare activation patterns of emotion reactivity during relevant trials of the Socioemotional Go/No-go Task (negative \> neutral) across experimental conditions (mindset vs control).

Time frame: Post Mindset Manipulation: baseline

Population: Some participants declined participation in these tasks and other data was lost due to technological error.

ArmMeasureValue (MEAN)Dispersion
Growth MindsetMean Difference in Parameter Estimates of BOLD Signal for Amygdala Activation- Go/No-go Task0.49 BOLD signal changeStandard Deviation 0.45
Brain EducationMean Difference in Parameter Estimates of BOLD Signal for Amygdala Activation- Go/No-go Task0.49 BOLD signal changeStandard Deviation 0.54
p-value: 0.96t-test, 2 sided
Primary

Mean Difference in Parameter Estimates of BOLD Signal for Amygdala Activation- Social Evaluation Task

The Social Evaluation Task (SET) examines emotion reactivity and regulation with social stimuli. Stimuli consisted of video clips with actors expressing criticism (negative condition), praise (positive condition) or neutral statements (neutral condition). Participants were asked to imagine the person was either an actor practicing lines (reframe condition), or a close friend (immerse condition). Participants were subsequently asked to rate how they felt on a 5 item Likert scale from Very Good to Very Bad. To reduce the influence of carryover effects across blocks, participants also engaged in a counting task at the conclusion of each block. We conducted ROI analyses of bilateral amygdalae to compare activation patterns during relevant trials of the Social Evaluation Task (negative immerse \> neutral immerse) across experimental conditions (mindset vs control).

Time frame: Post Mindset Manipulation: baseline

Population: Some participants declined participation in these tasks and other data was lost due to technological error.

ArmMeasureValue (MEAN)Dispersion
Growth MindsetMean Difference in Parameter Estimates of BOLD Signal for Amygdala Activation- Social Evaluation Task0.04 BOLD signal changeStandard Deviation 0.23
Brain EducationMean Difference in Parameter Estimates of BOLD Signal for Amygdala Activation- Social Evaluation Task-0.01 BOLD signal changeStandard Deviation 0.31
p-value: 0.265t-test, 2 sided
Primary

Mean Difference in Parameter Estimates of BOLD Signal for Frontal Parietal Network-Amygdala Connectivity- Go/No-go Task

The Socioemotional Go/No-go Task examines inhibitory control in the presence of socioemotional distractors. Participants were presented with a socially aversive image, or neutral image for 300ms. After the image, a white box with a black letter was superimposed on the image for 500 ms. Participants were instructed to respond quickly to every letter except an infrequent nontarget letter. Psychophysiological interaction (PPI) analysis was conducted in SPM12 to examine task-dependent changes in connectivity between amygdalae and frontoparietal network (FPN) during relevant trials of the Socioemotional Go/No-go Task (negative \> neutral) across experimental conditions (mindset vs control).

Time frame: Post Mindset Manipulation: baseline

ArmMeasureValue (MEAN)Dispersion
Growth MindsetMean Difference in Parameter Estimates of BOLD Signal for Frontal Parietal Network-Amygdala Connectivity- Go/No-go Task-0.17 BOLD signal changeStandard Deviation 0.61
Brain EducationMean Difference in Parameter Estimates of BOLD Signal for Frontal Parietal Network-Amygdala Connectivity- Go/No-go Task0.01 BOLD signal changeStandard Deviation 0.48
p-value: 0.048t-test, 2 sided
Primary

Mean Difference in Parameter Estimates of BOLD Signal for Frontal Parietal Network-Amygdala Connectivity- Social Evaluation Task

The Social Evaluation Task (SET) examines emotion reactivity and regulation with social stimuli. Stimuli consisted of video clips with actors expressing criticism (negative condition), praise (positive condition) or neutral statements (neutral condition). Participants were asked to imagine the person was either an actor practicing lines (reframe condition), or a close friend (immerse condition). Participants were subsequently asked to rate how they felt on a 5 item Likert scale from Very Good to Very Bad. To reduce the influence of carryover effects across blocks, participants also engaged in a counting task at the conclusion of each block. Psychophysiological interaction (PPI) analysis was conducted in SPM12 to examine task-dependent changes in connectivity between amygdalae and frontoparietal network (FPN) during relevant trials (negative reframe \> negative immerse) across experimental conditions (mindset vs control).

Time frame: Post Mindset Manipulation: baseline

ArmMeasureValue (MEAN)Dispersion
Growth MindsetMean Difference in Parameter Estimates of BOLD Signal for Frontal Parietal Network-Amygdala Connectivity- Social Evaluation Task0.01 BOLD signal changeStandard Deviation 0.41
Brain EducationMean Difference in Parameter Estimates of BOLD Signal for Frontal Parietal Network-Amygdala Connectivity- Social Evaluation Task-0.01 BOLD signal changeStandard Deviation 0.33
p-value: 0.76t-test, 2 sided
Primary

Mean Difference in Performance on Go/Nogo Task- Accuracy

The socioemotional Go/No-go presents participants with a socially appetitive image, socially aversive image, or neutral image. After, a letter was superimposed on the image. Participants were instructed to respond to every letter except for 'X'. Participants completed 4 blocks of each condition. Accurate responses to the letters after the socially appetitive images (positive accuracy), socially aversive image (negative accuracy) and neutral image (neutral accuracy) were indicated (0-1 scale). Mean scores across the four blocks were calculated, with higher scores indicating more accuracy. Will compare mean performance as reflected in accuracy across the two conditions (mindset and control)

Time frame: Post Mindset Manipulation: baseline

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Difference in Performance on Go/Nogo Task- Accuracypositive accuracy0.63 units on a scaleStandard Deviation 0.1
Growth MindsetMean Difference in Performance on Go/Nogo Task- Accuracynegative accuracy0.64 units on a scaleStandard Deviation 0.1
Growth MindsetMean Difference in Performance on Go/Nogo Task- Accuracyneutral accuracy0.65 units on a scaleStandard Deviation 0.11
Brain EducationMean Difference in Performance on Go/Nogo Task- Accuracypositive accuracy0.60 units on a scaleStandard Deviation 0.12
Brain EducationMean Difference in Performance on Go/Nogo Task- Accuracynegative accuracy0.62 units on a scaleStandard Deviation 0.12
Brain EducationMean Difference in Performance on Go/Nogo Task- Accuracyneutral accuracy0.63 units on a scaleStandard Deviation 0.13
Comparison: We are reporting the p-value for the group effect for accuracy (Growth Mindset vs. Brain Education). This is a test of between-subjects effect.p-value: 0.272ANOVA
Primary

Mean Difference in Performance on Go/Nogo Task- Reaction Time

The socioemotional Go/No-go presents participants with a socially appetitive image, socially aversive image, or neutral image. After the image, a white box with a black letter was superimposed on the image for 500 ms. Participants were instructed to respond as quickly as possible to every letter. Responses during these 500 ms were used for analysis. Mean reaction times (RT) in milliseconds to positive stimuli (pos.correctgoRT), negative stimuli (neg.correctgoRT) and neutral stimuli (neu.correctgoRT) were calculated, with higher numbers indicating slower RT. Will compare mean performance as reflected in reaction time across the two conditions (mindset and control)

Time frame: Post Mindset Manipulation: baseline

Population: 1 participant's data could not be used in the growth mindset condition in analyses. The means reported here for the growth mindset condition are slightly different than the means reported at baseline because here we are reporting the means of the participants analyzed, which does not include the one participant who's data could not be used.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Difference in Performance on Go/Nogo Task- Reaction Timenegative correct_go reaction time423.37 Reaction time in millisecondsStandard Deviation 35.72
Growth MindsetMean Difference in Performance on Go/Nogo Task- Reaction Timeneutral correct_go reaction time430.37 Reaction time in millisecondsStandard Deviation 33.42
Growth MindsetMean Difference in Performance on Go/Nogo Task- Reaction Timepositive correct_go reaction time427.40 Reaction time in millisecondsStandard Deviation 38.28
Brain EducationMean Difference in Performance on Go/Nogo Task- Reaction Timepositive correct_go reaction time433.44 Reaction time in millisecondsStandard Deviation 28.81
Brain EducationMean Difference in Performance on Go/Nogo Task- Reaction Timenegative correct_go reaction time431.78 Reaction time in millisecondsStandard Deviation 31.89
Brain EducationMean Difference in Performance on Go/Nogo Task- Reaction Timeneutral correct_go reaction time434.35 Reaction time in millisecondsStandard Deviation 37.7
Comparison: We are reporting the p-value for the group effect (Growth Mindset vs. Brain Education). This is a test of between-subjects effect.p-value: 0.227ANOVA
Primary

Mean Difference on Self-Reported Affect on Social Evaluation Task

The Social Evaluation Task examines emotion reactivity and regulation in the context of social stimuli. Stimuli consisted of video clips with actors expressing criticism (negative immerse or reframe), praise (positive immerse or reframe), or neutral statements (neutral immerse). In immerse trials, participants imagined that the person was a close friend. During the reframe trials, participants imagined that the person was an actor. After each trial, participants rated how they felt from 1 (Very Good) to 5 (Very Bad). Means of each condition were computed with higher scores indicating more negative emotions. In this analysis, we compared mean difference between criticism and praise vs. neutral trials across the two conditions (mindset and control) for the Social Evaluation Task

Time frame: Post Mindset Manipulation: baseline

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Difference on Self-Reported Affect on Social Evaluation Taskpositive immerse1.61 units on a scaleStandard Deviation 0.6
Growth MindsetMean Difference on Self-Reported Affect on Social Evaluation Taskpositive reframe2.39 units on a scaleStandard Deviation 0.64
Growth MindsetMean Difference on Self-Reported Affect on Social Evaluation Tasknegative reframe3.49 units on a scaleStandard Deviation 0.51
Growth MindsetMean Difference on Self-Reported Affect on Social Evaluation Taskneutral immerse2.90 units on a scaleStandard Deviation 0.33
Growth MindsetMean Difference on Self-Reported Affect on Social Evaluation Tasknegative immerse4.34 units on a scaleStandard Deviation 0.51
Brain EducationMean Difference on Self-Reported Affect on Social Evaluation Taskneutral immerse2.87 units on a scaleStandard Deviation 0.43
Brain EducationMean Difference on Self-Reported Affect on Social Evaluation Tasknegative immerse4.28 units on a scaleStandard Deviation 0.63
Brain EducationMean Difference on Self-Reported Affect on Social Evaluation Taskpositive immerse1.61 units on a scaleStandard Deviation 0.58
Brain EducationMean Difference on Self-Reported Affect on Social Evaluation Tasknegative reframe3.45 units on a scaleStandard Deviation 0.67
Brain EducationMean Difference on Self-Reported Affect on Social Evaluation Taskpositive reframe2.32 units on a scaleStandard Deviation 0.6
Comparison: We are reporting the p-value for the group effect (Growth Mindset vs. Brain Education) across self-reported affect on the SET task. This is a test of between-subjects effect.p-value: 0.321ANOVA
Secondary

Mean Change From Baseline to 2 Months in Emotional Self-efficacy Scale Scores (Measure Beliefs About Ability to Control Emotions)

Participants completed a measure assessing their perceived ability to manage emotions prior to the induction and again at a 2-month follow-up. Items were derived from the using and managing your own emotions subscale of the Youth-Emotional Self-efficacy Scale (5 items; Qualter et al., 2015). Participants rated the items on a 5-point Likert scale (1 = Disagree Strongly to 5 = Agree Strongly). Scores were computed as the mean of the items, with higher scores indicating greater emotion regulation self-efficacy. Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=5 High=better outcome.

Time frame: At baseline and in approximately 2 months

Population: Because only 69 participants in the growth mindset condition and 66 participants in the brain education completed the follow-up at 2-months, these analyses included only the same 69 and 66 participants who also completed the measure at baseline. Thus, the sample at baseline for pre-induction emotional self-efficacy is smaller in these analyses and the mean is different for baseline than it was initially at baseline because it includes a smaller portion of the sample.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Baseline to 2 Months in Emotional Self-efficacy Scale Scores (Measure Beliefs About Ability to Control Emotions)pre-induction emotional self-efficacy3.64 score on a scaleStandard Deviation 0.68
Growth MindsetMean Change From Baseline to 2 Months in Emotional Self-efficacy Scale Scores (Measure Beliefs About Ability to Control Emotions)post-induction emotional self-efficacy (2months)3.55 score on a scaleStandard Deviation 0.76
Brain EducationMean Change From Baseline to 2 Months in Emotional Self-efficacy Scale Scores (Measure Beliefs About Ability to Control Emotions)pre-induction emotional self-efficacy3.38 score on a scaleStandard Deviation 0.93
Brain EducationMean Change From Baseline to 2 Months in Emotional Self-efficacy Scale Scores (Measure Beliefs About Ability to Control Emotions)post-induction emotional self-efficacy (2months)3.40 score on a scaleStandard Deviation 0.93
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on emotional self-efficacy scores from time 1 to time 2. This is a test of between by within-subjects interaction effect.p-value: 0.403ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on emotional self-efficacy scores from time 1 to time 2. This is a test of between by within-subjects interaction effect. Clarity of the psycho-educational lessons was included as a covariate.p-value: 0.19ANCOVA
Secondary

Mean Change From Baseline to 2 Months in Emotional Self-efficacy Vignettes Scores

To assess emotion regulation self-efficacy participants completed a self-efficacy measure adapted from Tamir and colleagues (2007). Prior to the induction and again. at a 2-month follow-up, participants were asked to rate 12 emotion-eliciting events drawn from daily life. Three scenarios were adapted from the Tamir self-efficacy measure (Tamir et al. 2007. Participants rated how confident they were in their ability to control their emotions in each scenario on a 5-point scale (1 = Not at All to 5 = Very Much). Scores were computed as the mean of the items, with higher scores reflecting greater self-efficacy.Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=5 High=better outcome

Time frame: At baseline and in approximately 2 months

Population: Because only 69 participants in the growth mindset condition and 66 participants in the brain education completed the follow-up at 2-months, the number analyzed includes only the same 69 and 66 participants who also completed the measure at baseline. Thus, the sample at baseline for pre-induction emotional self-efficacy vignettes is smaller in these analyses and the mean is different for baseline than it was initially at baseline because it includes a smaller portion of the sample.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Baseline to 2 Months in Emotional Self-efficacy Vignettes Scorespre-induction emotional self-efficacy vignette score2.95 units on a scaleStandard Deviation 0.61
Growth MindsetMean Change From Baseline to 2 Months in Emotional Self-efficacy Vignettes Scorespost-induction emotional self-efficacy vignette score (2months)2.93 units on a scaleStandard Deviation 0.69
Brain EducationMean Change From Baseline to 2 Months in Emotional Self-efficacy Vignettes Scorespre-induction emotional self-efficacy vignette score2.70 units on a scaleStandard Deviation 0.65
Brain EducationMean Change From Baseline to 2 Months in Emotional Self-efficacy Vignettes Scorespost-induction emotional self-efficacy vignette score (2months)2.69 units on a scaleStandard Deviation 0.66
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on emotional self-efficacy vignette scores from time 1 to time 2. This is a test of between by within-subjects interaction effect.p-value: 0.916ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on emotional self-efficacy vignette scores from time 1 to time 2. This is a test of between by within-subjects interaction effect. Clarity of the psycho-educational lessons was included as a covariate.p-value: 0.343ANCOVA
Secondary

Mean Change From Baseline to 2 Months in Emotion Mindset Scale Scores

Participants completed a six-item fixed emotion mindset measure (EMS-fixed) measure, prior to (pre-induction EMS) the induction lessons and again at at 2-month follow-up. Items were drawn from the Implicit Theories of Emotion Scale (Tamir et al., 2007) and the Emotion Mindset Scale (EMS; Livingstone, 2013). Participants rated each item on a 6-point scale (1 = Strongly Disagree to 6 =Strongly Agree). Means were computed for these items, with higher scores representing a higher fixed emotion mindset mindset. Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=6 High=better outcome

Time frame: At baseline and in approximately 2 months

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Baseline to 2 Months in Emotion Mindset Scale Scorespre-induction child fixed emotion mindset3.03 score on a scaleStandard Deviation 0.96
Growth MindsetMean Change From Baseline to 2 Months in Emotion Mindset Scale Scorespost-induction child fixed emotion mindset (2months)2.74 score on a scaleStandard Deviation 1
Brain EducationMean Change From Baseline to 2 Months in Emotion Mindset Scale Scorespre-induction child fixed emotion mindset3.03 score on a scaleStandard Deviation 0.92
Brain EducationMean Change From Baseline to 2 Months in Emotion Mindset Scale Scorespost-induction child fixed emotion mindset (2months)3.17 score on a scaleStandard Deviation 1.01
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) for fixed emotion mindset scores from time 1 to time 2. This is a test of between by within-subjects interaction effect.p-value: 0.002ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on fixed emotion mindset scores from time 1 to time 2. This is a test of between by within-subjects interaction effect. Clarity of the psycho-educational lessons included as a covariate.p-value: 0.005ANCOVA
Secondary

Mean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies Scores

To assess emotion (dys)regulation, participants completed a novel 44-item emotion regulation measure at baseline and again at a 2-month follow-up. Items were rated on a 5-point scale (1 = Not at All to 5 = Very Much). Factor analyses yielded three emotion regulation strategies factors- proactive engagement, involuntary dysregulation, and disengagement. Scores were computed as the mean of the items on each factor (1 = Not at All to 5 = Very Much), with higher scores reflecting higher levels of type of response. Higher scores on proactive engagement are considered adaptive and higher scores on involuntary dysregulation are maladaptive. Will compare mean change scores across the two conditions (mindset and control)

Time frame: At baseline and in approximately 2 months

Population: Some participants did not complete all of the items and thus their emotion regulation strategies factors could not be calculated. Because only 72-73 participants in the growth mindset condition and 70-71 participants in the brain education completed the follow-up at 2-months (some participants filled out half the measure), the number analyzed includes only the same 72-73 and 70-71 participants who also completed the measure at baseline.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresPre-induction ERD proactive engagement2.97 score on a scaleStandard Deviation 0.8
Growth MindsetMean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresPost-induction ERD proactive engagement (2Months)3.07 score on a scaleStandard Deviation 0.74
Growth MindsetMean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresPre-induction ERD involuntary dysregulation2.40 score on a scaleStandard Deviation 0.63
Growth MindsetMean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresPost-induction ERD involuntary dysregulation (2months)2.44 score on a scaleStandard Deviation 0.68
Growth MindsetMean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresPre-induction ERD disengagement3.28 score on a scaleStandard Deviation 0.62
Growth MindsetMean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresPost-induction ERD disengagement (2months)3.30 score on a scaleStandard Deviation 0.66
Brain EducationMean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresPre-induction ERD disengagement3.05 score on a scaleStandard Deviation 0.73
Brain EducationMean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresPre-induction ERD proactive engagement2.69 score on a scaleStandard Deviation 0.78
Brain EducationMean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresPost-induction ERD involuntary dysregulation (2months)2.68 score on a scaleStandard Deviation 0.79
Brain EducationMean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresPost-induction ERD proactive engagement (2Months)2.85 score on a scaleStandard Deviation 0.75
Brain EducationMean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresPost-induction ERD disengagement (2months)3.17 score on a scaleStandard Deviation 0.68
Brain EducationMean Change From Baseline to 2 Months in Self-Reported Emotion Regulation Strategies ScoresPre-induction ERD involuntary dysregulation2.45 score on a scaleStandard Deviation 0.77
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on ERD proactive engagement scores from time 1 to time 2. This is a test of between by within-subjects interaction effect.p-value: 0.566ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on ERD involuntary dysregulation scores from time 1 to time 2. This is a test of between by within-subjects interaction effect.p-value: 0.048ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on ERD involuntary dysregulation scores from time 1 to time 2. This is a test of between by within-subjects interaction effect. Clarity of the psycho-educational lessons was included as a covariate.p-value: 0.266ANCOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on ERD disengagement scores from time 1 to time 2. This is a test of between by within-subjects interaction effect.p-value: 0.402ANOVA
Secondary

Mean Change From Baseline to 4 Months in Emotional Self-efficacy Scale Scores (Measure Beliefs About Ability to Control Emotions)

Participants completed a measure assessing their perceived ability to manage emotions prior to the induction and again at a 4-month follow-up. Items were derived from the using and managing your own emotions subscale of the Youth-Emotional Self-efficacy Scale (5 items; Qualter et al., 2015). Participants rated the items on a 5-point Likert scale (1 = Disagree Strongly to 5 = Agree Strongly). Scores were computed as the mean of the items, with higher scores indicating greater emotion regulation self-efficacy. Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=5 High=better outcome.

Time frame: At baseline and in approximately 4 months

Population: Because only 70 participants in the growth mindset condition and 70 participants in the brain education completed the follow-up at 4-months, the number analyzed includes only the same 70 and 70 participants who also completed the measure at baseline. Thus, the sample at baseline for pre-induction emotional self-efficacy is smaller in these analyses and the mean is different for baseline than it was initially at baseline because it includes a smaller portion of the sample.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Baseline to 4 Months in Emotional Self-efficacy Scale Scores (Measure Beliefs About Ability to Control Emotions)pre-induction emotional self-efficacy3.64 score on a scaleStandard Deviation 0.67
Growth MindsetMean Change From Baseline to 4 Months in Emotional Self-efficacy Scale Scores (Measure Beliefs About Ability to Control Emotions)post-induction emotional self-efficacy (4months)3.63 score on a scaleStandard Deviation 0.69
Brain EducationMean Change From Baseline to 4 Months in Emotional Self-efficacy Scale Scores (Measure Beliefs About Ability to Control Emotions)pre-induction emotional self-efficacy3.37 score on a scaleStandard Deviation 0.91
Brain EducationMean Change From Baseline to 4 Months in Emotional Self-efficacy Scale Scores (Measure Beliefs About Ability to Control Emotions)post-induction emotional self-efficacy (4months)3.39 score on a scaleStandard Deviation 0.94
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on emotional self-efficacy scores from time 1 to time 3. This is a test of between by within-subjects interaction effect.p-value: 0.784ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on emotional self-efficacy scores from time 1 to time 3. This is a test of between by within-subjects interaction effect. Clarity of the psycho-educational lessons was included as a covariate.p-value: 0.586ANCOVA
Secondary

Mean Change From Baseline to 4 Months in Emotional Self-efficacy Vignettes Scores

To assess emotion regulation self-efficacy participants completed a self-efficacy measure adapted from Tamir and colleagues (2007). Prior to the induction and again at a 4-month follow-up, participants were asked to rate 12 emotion-eliciting events drawn from daily life. Three scenarios were adapted from the Tamir self-efficacy measure (Tamir et al. 2007. Participants rated how confident they were in their ability to control their emotions in each scenario on a 5-point scale (1 = Not at All to 5 = Very Much). Scores were computed as the mean of the items, with higher scores reflecting greater self-efficacy.Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=5 High=better outcome

Time frame: At baseline and in approximately 4 months

Population: Because only 69 participants in the growth mindset condition and 69 participants in the brain education completed the follow-up at 4-months, the number analyzed includes only the same 70 and 70 participants who also completed the measure at baseline. Thus, the sample at baseline for pre-induction emotional self-efficacy vignettes is smaller in these analyses and the mean is different for baseline than it was initially at baseline because it includes a smaller portion of the sample.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Baseline to 4 Months in Emotional Self-efficacy Vignettes Scorespre-induction emotional self-efficacy vignettes score2.95 score on a scaleStandard Deviation 0.59
Growth MindsetMean Change From Baseline to 4 Months in Emotional Self-efficacy Vignettes Scorespost-induction emotional self-efficacy vignettes score (4months)3.19 score on a scaleStandard Deviation 0.68
Brain EducationMean Change From Baseline to 4 Months in Emotional Self-efficacy Vignettes Scorespre-induction emotional self-efficacy vignettes score2.71 score on a scaleStandard Deviation 0.62
Brain EducationMean Change From Baseline to 4 Months in Emotional Self-efficacy Vignettes Scorespost-induction emotional self-efficacy vignettes score (4months)2.74 score on a scaleStandard Deviation 0.6
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on emotional self-efficacy vignette scores from time 1 to time 3. This is a test of between by within-subjects interaction effect.p-value: 0.048ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on emotional self-efficacy vignette scores from time 1 to time 3. This is a test of between by within-subjects interaction effect. Clarity of the psycho-educational lesson was included as a covariate.p-value: 0.153ANCOVA
Secondary

Mean Change From Baseline to 4 Months in Emotion Mindset Scores

Participants completed a six-item fixed emotion mindset measure (EMS-fixed) measure, prior to (pre-induction EMS) the induction lessons and again at at 4-month follow-up. Items were drawn from the Implicit Theories of Emotion Scale (Tamir et al., 2007) and the Emotion Mindset Scale (EMS; Livingstone, 2013). Participants rated each item on a 6-point scale (1 = Strongly Disagree to 6 =Strongly Agree). Means were computed for these items, with higher scores representing a higher fixed emotion mindset mindset. Will compare mean change scores across the two conditions (mindset and control) Minimum=1 Maximum=6 High=better outcome

Time frame: At baseline and in approximately 4 months

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Baseline to 4 Months in Emotion Mindset Scorespre-induction child fixed emotion mindset3.03 score on a scaleStandard Deviation 0.96
Growth MindsetMean Change From Baseline to 4 Months in Emotion Mindset Scorespost-induction child fixed emotion mindset (4months)2.80 score on a scaleStandard Deviation 0.98
Brain EducationMean Change From Baseline to 4 Months in Emotion Mindset Scorespre-induction child fixed emotion mindset3.03 score on a scaleStandard Deviation 0.92
Brain EducationMean Change From Baseline to 4 Months in Emotion Mindset Scorespost-induction child fixed emotion mindset (4months)3.11 score on a scaleStandard Deviation 0.92
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on fixed emotion mindset scores from time 1 to time 3. This is a test of between by within-subjects interaction effect.p-value: 0.033ANOVA
Secondary

Mean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies Scores

To assess emotion (dys)regulation, participants completed a novel 44-item emotion regulation measure at baseline and again at a 4-month follow-up. Items were rated on a 5-point scale (1 = Not at All to 5 = Very Much). Factor analyses yielded three emotion regulation strategies factors- proactive engagement, involuntary dysregulation, and disengagement. Scores were computed as the mean of the items on each factor (1 = Not at All to 5 = Very Much), with higher scores reflecting higher levels of type of response. Higher scores on proactive engagement are considered adaptive and higher scores on involuntary dysregulation are maladaptive. Will compare mean change scores across the two conditions (mindset and control) Will compare mean change scores across the two conditions (mindset and control)

Time frame: At baseline and in approximately 4 months

Population: Some participants did not complete all of the items and thus their emotion regulation strategies factors could not be calculated. Because only 71-72 participants in the growth mindset condition (some participants filled out half the measure) and 74 participants in the brain education completed the follow-up at 4-months, the number analyzed includes only the same 71-72 and 74 participants who also completed the measure at baseline.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresPre-induction ERD proactive engagement2.96 score on a scaleStandard Deviation 0.79
Growth MindsetMean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresPost-induction ERD proactive engagement (4months)3.12 score on a scaleStandard Deviation 0.72
Growth MindsetMean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresPre-induction ERD involuntary dysregulation2.42 score on a scaleStandard Deviation 0.64
Growth MindsetMean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresPost-induction ERD involuntary dysregulation (4months)2.47 score on a scaleStandard Deviation 0.79
Growth MindsetMean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresPre-induction ERD disengagement3.23 score on a scaleStandard Deviation 0.68
Growth MindsetMean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresPost-induction ERD disengagement (4months)3.28 score on a scaleStandard Deviation 0.66
Brain EducationMean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresPre-induction ERD disengagement2.99 score on a scaleStandard Deviation 0.71
Brain EducationMean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresPre-induction ERD proactive engagement2.73 score on a scaleStandard Deviation 0.78
Brain EducationMean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresPost-induction ERD involuntary dysregulation (4months)2.64 score on a scaleStandard Deviation 0.83
Brain EducationMean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresPost-induction ERD proactive engagement (4months)2.78 score on a scaleStandard Deviation 0.74
Brain EducationMean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresPost-induction ERD disengagement (4months)3.15 score on a scaleStandard Deviation 0.75
Brain EducationMean Change From Baseline to 4 Months in Self-Reported Emotion Regulation Strategies ScoresPre-induction ERD involuntary dysregulation2.49 score on a scaleStandard Deviation 0.78
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on ERD proactive engagement from time 1 to time 3. This is a test of between by within-subjects interaction effect.p-value: 0.363ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on ERD involuntary dysregulation scores from time 1 to time 3. This is a test of between by within-subjects interaction effect.p-value: 0.363ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on ERD involuntary dysregulation scores from time 1 to time 3. This is a test of between by within-subjects interaction effect. Clarity of the psycho-educational lessons was included as a covariate.p-value: 0.583ANCOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on ERD disengagement scores from time 1 to time 3. This is a test of between by within-subjects interaction effect.p-value: 0.379ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (pre-manipulation and post-manipulation) on ERD disengagement scores from time 1 to time 3. This is a test of between by within-subjects interaction effect. Clarity of the psycho-educational lessons was included as a covariate.p-value: 0.246ANCOVA
Other Pre-specified

Group Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation Task

The Social Evaluation Task (SET) examines emotion reactivity and regulation with social stimuli. Stimuli consisted of video clips with actors expressing criticism (negative condition), praise (positive condition) or neutral statements (neutral condition). Participants were asked to imagine the person was either an actor practicing lines (reframe condition), or a close friend (immerse condition). Participants were subsequently asked to rate how they felt on a 5 item Likert scale from Very Good to Very Bad. To reduce the influence of carryover effects across blocks, participants also engaged in a counting task at the conclusion of each block. We conducted exploratory whole-brain voxelwise analyses in SPM12 to compare activation patterns during relevant trials of the Social Evaluation Task (negative immerse \> neutral immerse and negative reframe \> negative immerse) across experimental conditions (mindset \> control).

Time frame: Post Mindset Manipulation: baseline

Population: Some participants declined participation in these tasks and other data was lost due to technological error.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetGroup Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation TaskAnterior Cingulate/Medial Frontal Gyrus0.37167 BOLD signal changeStandard Deviation 0.49233
Growth MindsetGroup Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation TaskMiddle Frontal Gyrus (Left)0.17254 BOLD signal changeStandard Deviation 0.30488
Growth MindsetGroup Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation TaskPosterior Cingulate/Cingulate0.16448 BOLD signal changeStandard Deviation 0.3739
Growth MindsetGroup Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation TaskMiddle Temporal Gyrus (Left)0.08163 BOLD signal changeStandard Deviation 0.54079
Growth MindsetGroup Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation TaskMiddle Frontal Gyrus (Right)0.13315 BOLD signal changeStandard Deviation 0.35573
Growth MindsetGroup Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation TaskSuperior/Middle Temporal Gyrus (Right)0.29583 BOLD signal changeStandard Deviation 0.49264
Brain EducationGroup Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation TaskMiddle Frontal Gyrus (Right)-0.13705 BOLD signal changeStandard Deviation 0.39
Brain EducationGroup Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation TaskAnterior Cingulate/Medial Frontal Gyrus0.01202 BOLD signal changeStandard Deviation 0.51865
Brain EducationGroup Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation TaskMiddle Temporal Gyrus (Left)-0.33910 BOLD signal changeStandard Deviation 0.60712
Brain EducationGroup Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation TaskMiddle Frontal Gyrus (Left)-0.07882 BOLD signal changeStandard Deviation 0.33388
Brain EducationGroup Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation TaskSuperior/Middle Temporal Gyrus (Right)-0.06817 BOLD signal changeStandard Deviation 0.56753
Brain EducationGroup Differences in Parameter Estimates of BOLD Signal for Whole-Brain Analyses- Social Evaluation TaskPosterior Cingulate/Cingulate-0.09570 BOLD signal changeStandard Deviation 0.4507
p-value: 0.0000222t-test, 2 sided
p-value: 0.0000117t-test, 2 sided
p-value: 0t-test, 2 sided
p-value: 0.0000186t-test, 2 sided
p-value: 0t-test, 2 sided
p-value: 0.0000161t-test, 2 sided
p-value: >0.001t-test, 2 sided
Other Pre-specified

Mean Change From Baseline to 2 Months in Anxiety Symptoms Scores

Participants completed the Revised Child Manifest Anxiety Scale (RCMAS; Reynolds & Richmond, 1985) at baseline and again at a 2-month follow-up. The RCMAS includes 28 items assessing anxiety symptoms (e.g., I often worry about something bad happening to me.) rated on a dichotomous scale (0 = No, 1 = Yes). Total anxiety scores were created by taking the sum of the items, with higher scores reflecting higher levels of anxiety. The RCMAS shows strong internal consistency (Reynolds & Richmond, 1978) and test-retest reliability (Wisniewski et al., 1987). Will compare mean change scores across the two conditions (mindset and control)

Time frame: At baseline and in approximately 2 months

Population: Because only 72 participants in the growth mindset condition and 69 participants in the brain education completed the follow-up at 2-months, the number analyzed includes only the same 72 and 69 participants who completed the measure at baseline and follow-up. The number of participants and means are different at baseline because these include a smaller set of the sample than initially at baseline.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Baseline to 2 Months in Anxiety Symptoms ScoresBaseline anxiety (RCMAS)13.04 score on a scaleStandard Deviation 5.98
Growth MindsetMean Change From Baseline to 2 Months in Anxiety Symptoms ScoresFollow-up anxiety (RCMAS; 2months)13.60 score on a scaleStandard Deviation 7.17
Brain EducationMean Change From Baseline to 2 Months in Anxiety Symptoms ScoresBaseline anxiety (RCMAS)13.98 score on a scaleStandard Deviation 6.37
Brain EducationMean Change From Baseline to 2 Months in Anxiety Symptoms ScoresFollow-up anxiety (RCMAS; 2months)15.21 score on a scaleStandard Deviation 7.55
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (baseline and follow-up) on anxiety levels from time 1 to time 2. This is a test of between by within-subjects interaction effect.p-value: 0.439ANOVA
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (baseline and follow-up) on anxiety levels from time 1 to time 2. This is a test of between by within-subjects interaction effect. Clarity of the psycho-educational lessons was included as a covariate.p-value: 0.545ANCOVA
Other Pre-specified

Mean Change From Baseline to 2 Months in Depressive Symptoms Scores

Participants completed the short form of the Mood and Feelings Questionnaire (SMFQ; Angold et al., 1995) to assess depressive symptoms (13 items) at baseline and again at a 2-month follow-up. The original version was modified (Liang & Eley, 2005) to provide a 4-point response format (1 = Not at All, 2 = A Little Bit, 3 = Pretty Much, 4 = Very Much). Scores were computed as the mean of the items, with higher scores reflecting higher levels of depressive symptoms. Will compare mean change scores across the two conditions (mindset and control) at baseline and the two month follow-up.

Time frame: At baseline and in approximately 2 months

Population: Because only 71 participants in the growth mindset condition and 70 participants in the brain education completed the follow-up at 2-months, the number analyzed includes only the same 71 and 70 participants who completed the measure at baseline and follow-up. The number of participants and means are different at baseline because these include a smaller set of the sample than initially at baseline.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Baseline to 2 Months in Depressive Symptoms ScoresBaseline depression (SMFQ)1.81 score on a scaleStandard Deviation 0.69
Growth MindsetMean Change From Baseline to 2 Months in Depressive Symptoms ScoresFollow-up depression (SMFQ; 2months)1.91 score on a scaleStandard Deviation 0.74
Brain EducationMean Change From Baseline to 2 Months in Depressive Symptoms ScoresBaseline depression (SMFQ)1.84 score on a scaleStandard Deviation 0.67
Brain EducationMean Change From Baseline to 2 Months in Depressive Symptoms ScoresFollow-up depression (SMFQ; 2months)2.00 score on a scaleStandard Deviation 0.74
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (baseline and follow-up) on depression levels from time 1 to time 2. This is a test of between by within-subjects interaction effect.p-value: 0.56ANOVA
Other Pre-specified

Mean Change From Baseline to 4 Months in Anxiety Symptoms Scores

Participants completed the Revised Child Manifest Anxiety Scale (RCMAS; Reynolds & Richmond, 1985) at baseline and again at a 4-month follow-up. The RCMAS includes 28 items assessing anxiety symptoms (e.g., I often worry about something bad happening to me.) rated on a dichotomous scale (0 = No, 1 = Yes). Total anxiety scores were created by taking the sum of the items, with higher scores reflecting higher levels of anxiety. The RCMAS shows strong internal consistency (Reynolds & Richmond, 1978) and test-retest reliability (Wisniewski et al., 1987). Will compare mean change scores across the two conditions (mindset and control). Will compare mean change scores across the two conditions (mindset and control)

Time frame: At baseline and in approximately 4 months

Population: Because only 70 participants in the growth mindset condition and 73 participants in the brain education completed the follow-up at 4-months, the number analyzed includes only the same 70 and 73 participants who completed the measure at baseline and follow-up. The number of participants and means are different at baseline because these include a smaller set of the sample than initially at baseline.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Baseline to 4 Months in Anxiety Symptoms ScoresBaseline anxiety (RCMAS)13.50 score on a scaleStandard Deviation 6.09
Growth MindsetMean Change From Baseline to 4 Months in Anxiety Symptoms ScoresFollow-up anxiety (RCMAS; 4months)13.53 score on a scaleStandard Deviation 7.36
Brain EducationMean Change From Baseline to 4 Months in Anxiety Symptoms ScoresBaseline anxiety (RCMAS)13.60 score on a scaleStandard Deviation 6.3
Brain EducationMean Change From Baseline to 4 Months in Anxiety Symptoms ScoresFollow-up anxiety (RCMAS; 4months)13.92 score on a scaleStandard Deviation 7.03
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (baseline and follow-up) on anxiety levels from time 1 to time 3. This is a test of between by within-subjects interaction effect.p-value: 0.74ANOVA
Other Pre-specified

Mean Change From Baseline to 4 Months in Depressive Symptoms Scores

Participants completed the short form of the Mood and Feelings Questionnaire (SMFQ; Angold et al., 1995) to assess depressive symptoms (13 items) at baseline and again at a 4-month follow-up. The original version was modified (Liang & Eley, 2005) to provide a 4-point response format (1 = Not at All, 2 = A Little Bit, 3 = Pretty Much, 4 = Very Much). Scores were computed as the mean of the items, with higher scores reflecting higher levels of depressive symptoms. Will compare mean change scores across the two conditions (mindset and control) at baseline and the four-month follow-up.

Time frame: At baseline and in approximately 4 months

Population: Because only 71 participants in the growth mindset condition and 72 participants in the brain education completed the follow-up at 4-months, the number analyzed includes only the same 71 and 72 participants who completed the measure at baseline and follow-up. The number of participants and means are different at baseline because these include a smaller set of the sample than initially at baseline.

ArmMeasureGroupValue (MEAN)Dispersion
Growth MindsetMean Change From Baseline to 4 Months in Depressive Symptoms ScoresBaseline depression (SMFQ)1.81 score on a scaleStandard Deviation 0.68
Growth MindsetMean Change From Baseline to 4 Months in Depressive Symptoms ScoresFollow-up depression (SMFQ; 4months)1.94 score on a scaleStandard Deviation 0.72
Brain EducationMean Change From Baseline to 4 Months in Depressive Symptoms ScoresBaseline depression (SMFQ)1.82 score on a scaleStandard Deviation 0.67
Brain EducationMean Change From Baseline to 4 Months in Depressive Symptoms ScoresFollow-up depression (SMFQ; 4months)2.05 score on a scaleStandard Deviation 0.82
Comparison: We are reporting the p-value for the group (Growth Mindset vs. Brain Education) by time effect (baseline and follow-up) on depression levels from time 1 to time 3. This is a test of between by within-subjects interaction effect.p-value: 0.327ANOVA
Other Pre-specified

Mean Difference in Parameter Estimates of BOLD Signal Cingulo-Opercular Network-Amygdala Connectivity- Resting State

Data were collected using a Siemens Prisma MRI 3T scanner and preprocessed with fMRIprep. We conducted connectivity analysis between the cingulo-opercular network (CON) and bilateral amygdala to explore difference in mean intrinsic CON-amygdala neural connectivity across experimental conditions (mindset vs control). 12 ROI masks were generated from the CON network of a modified Schaefer atlas. Separate right/left amygdala seeds were defined with the AAL1 atlas.

Time frame: Post Mindset Manipulation: baseline

Population: Some participants declined participation in these tasks and other data was lost due to technological error.

ArmMeasureValue (MEAN)Dispersion
Growth MindsetMean Difference in Parameter Estimates of BOLD Signal Cingulo-Opercular Network-Amygdala Connectivity- Resting State0.20 BOLD signal changeStandard Deviation 0.12
Brain EducationMean Difference in Parameter Estimates of BOLD Signal Cingulo-Opercular Network-Amygdala Connectivity- Resting State0.20 BOLD signal changeStandard Deviation 0.1
Comparison: A two-sample t-test was conducted to compare average connectivity (between the amygdala and the CON network) during resting state between the mindset and control groups.p-value: 0.92t-test, 2 sided
Other Pre-specified

Mean Difference in Parameter Estimates of BOLD Signal Cingulo-Opercular Network-Amygdala Connectivity- Social Evaluation Task

The Social Evaluation Task (SET) examines emotion reactivity and regulation with social stimuli. Stimuli consisted of video clips with actors expressing criticism (negative condition), praise (positive condition) or neutral statements (neutral condition). Participants were asked to imagine the person was either an actor practicing lines (reframe condition), or a close friend (immerse condition). Participants were subsequently asked to rate how they felt on a 5 item Likert scale from Very Good to Very Bad. To reduce the influence of carryover effects across blocks, participants also engaged in a counting task at the conclusion of each block. Psychophysiological interaction (PPI) analysis was conducted in SPM12 to examine task-dependent changes in connectivity between amygdalae and cingulo-opercular network (CON) during relevant trials (negative reframe \> negative immerse) across experimental conditions (mindset vs control).

Time frame: Post Mindset Manipulation: baseline

Population: Some participants declined participation in these tasks and other data was lost due to technological error.

ArmMeasureValue (MEAN)Dispersion
Growth MindsetMean Difference in Parameter Estimates of BOLD Signal Cingulo-Opercular Network-Amygdala Connectivity- Social Evaluation Task-0.005 BOLD signal changeStandard Deviation 0.4
Brain EducationMean Difference in Parameter Estimates of BOLD Signal Cingulo-Opercular Network-Amygdala Connectivity- Social Evaluation Task0.004 BOLD signal changeStandard Deviation 0.34
p-value: 0.88t-test, 2 sided
Other Pre-specified

Mean Difference in Parameter Estimates of BOLD Signal for Cingulo-Opercular Network Activation- Go/No go Task

The Socioemotional Go/No-go Task examines inhibitory control in the presence of socioemotional distractors. Participants were presented with a socially aversive image, or neutral image for 300ms. After the image, a white box with a black letter was superimposed on the image for 500 ms. Participants were instructed to respond quickly to every letter except an infrequent nontarget letter. We conducted ROI analyses of the cingulo-opercular network (CON) to compare activation patterns during relevant trials of the Socioemotional Go/No-go Task (negative \> neutral) across experimental conditions (mindset vs control).

Time frame: Post Mindset Manipulation: baseline

Population: Some participants declined participation in these tasks and other data was lost due to technological error.

ArmMeasureValue (MEAN)Dispersion
Growth MindsetMean Difference in Parameter Estimates of BOLD Signal for Cingulo-Opercular Network Activation- Go/No go Task-0.11 BOLD signal changeStandard Deviation 0.62
Brain EducationMean Difference in Parameter Estimates of BOLD Signal for Cingulo-Opercular Network Activation- Go/No go Task-0.02 BOLD signal changeStandard Deviation 0.68
p-value: 0.43t-test, 2 sided
Other Pre-specified

Mean Difference in Parameter Estimates of BOLD Signal for Cingulo-Opercular Network Activation- Resting State

We conducted ROI analyses of the cingulo-opercular network (CON) to explore difference in mean intrinsic neural activity across experimental conditions (mindset vs control). Data were collected using a Siemens Prisma MRI 3T scanner and preprocessed with fMRIprep. 12 ROI masks were generated from the CON network of a modified Schaefer atlas.

Time frame: Post Mindset Manipulation: baseline

Population: Some participants declined participation in these tasks and other data was lost due to technological error.

ArmMeasureValue (MEAN)Dispersion
Growth MindsetMean Difference in Parameter Estimates of BOLD Signal for Cingulo-Opercular Network Activation- Resting State-0.0000003502 BOLD signal changeStandard Error 0.000022
Brain EducationMean Difference in Parameter Estimates of BOLD Signal for Cingulo-Opercular Network Activation- Resting State0.000003274 BOLD signal changeStandard Error 0.00001911
p-value: 0.29t-test, 2 sided
Other Pre-specified

Mean Difference in Parameter Estimates of BOLD Signal for Cingulo-Opercular Network Activation- Social Evaluation Task

The Social Evaluation Task (SET) examines emotion reactivity and regulation with social stimuli. Stimuli consisted of video clips with actors expressing criticism (negative condition), praise (positive condition) or neutral statements (neutral condition). Participants were asked to imagine the person was either an actor practicing lines (reframe condition), or a close friend (immerse condition). Participants were subsequently asked to rate how they felt on a 5 item Likert scale from Very Good to Very Bad. To reduce the influence of carryover effects across blocks, participants also engaged in a counting task at the conclusion of each block. We conducted ROI analyses of the cingulo-opercular network (CON) to compare activation patterns of emotion reactivity during relevant trials (negative reframe \> negative immerse) across experimental conditions (mindset vs control).

Time frame: Post Mindset Manipulation: baseline

Population: Some participants declined participation in these tasks and other data was lost due to technological error.

ArmMeasureValue (MEAN)Dispersion
Growth MindsetMean Difference in Parameter Estimates of BOLD Signal for Cingulo-Opercular Network Activation- Social Evaluation Task-0.07 BOLD signal changeStandard Deviation 0.41
Brain EducationMean Difference in Parameter Estimates of BOLD Signal for Cingulo-Opercular Network Activation- Social Evaluation Task-0.02 BOLD signal changeStandard Deviation 0.37
p-value: 0.455t-test, 2 sided
Other Pre-specified

Mean Difference in Parameter Estimates of BOLD Signal for Cingulo-Opercular Network-Amygdala Connectivity- Go/no go Task

The Socioemotional Go/No-go Task examines inhibitory control in the presence of socioemotional distractors. Participants were presented with a socially aversive image, or neutral image for 300ms. After the image, a white box with a black letter was superimposed on the image for 500 ms. Participants were instructed to respond quickly to every letter except an infrequent nontarget letter. Psychophysiological interaction (PPI) analysis was conducted in SPM12 to examine task-dependent changes in connectivity between amygdalae and cingulo-opercular network (CON) during relevant trials (negative \> neutral) across experimental conditions (mindset vs control).

Time frame: Post Mindset Manipulation: baseline

Population: Some participants declined participation in these tasks and other data was lost due to technological error.

ArmMeasureValue (MEAN)Dispersion
Growth MindsetMean Difference in Parameter Estimates of BOLD Signal for Cingulo-Opercular Network-Amygdala Connectivity- Go/no go Task-0.12 BOLD signal changeStandard Deviation 0.6
Brain EducationMean Difference in Parameter Estimates of BOLD Signal for Cingulo-Opercular Network-Amygdala Connectivity- Go/no go Task0.03 BOLD signal changeStandard Deviation 0.49
p-value: 0.11t-test, 2 sided

Source: ClinicalTrials.gov · Data processed: May 20, 2026