Evaluation of the Impact of Pancreatectomy on Systemic Immunity

Pancreatic Surgery: Evaluation of the Impact of Pancreatectomy on Systemic Immunity

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03978702

Acronym

IMMUNOPANC

Enrollment

Registered

2019-06-07

Start date

2021-02-24

Completion date

2022-07-27

Last updated

2022-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreas Cancer, Pancreatectomy; Hyperglycemia

Keywords

Pancreatectomy, Immune system

Brief summary

The study aims at establishing the profile of the immune reaction that occurs in the early surgical suites after pancreatectomy. Blood samples will be collected before surgery, (Day-1), at day0, and after surgery at Day 1, Day 3, Day 7 at 1 year after pancreatectomy. Mass cytometry, genomic and transcriptomic approaches will be used to evaluate the immune systemic modulation after surgery.

Interventions

OTHERBlood sampling

20 mL will be collected at each time point (day-1,day 0, day 1, day 3, day 7, 1 year after pancreatectomy)

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient with an indication of pancreatectomy * Signed consent form

Exclusion criteria

* Neoadjuvant treatment * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Measurement of immune effectors (Tcells, NK) levels after pancreatectomy	1 year	Evaluation of immune effectors my mass cytometry after pancreatectomy (compared to baseline)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 13, 2026