Anaemia of Renal Disease, Anemia, Anemia of Chronic Inflammation, Folic Acid Deficiency, Iron-deficiency, Vitamin B 12 Deficiency
Conditions
Keywords
Anemia
Brief summary
Preoperative anaemia is common in surgery, with a prevalence between 10 and 50 %, and is an independent risk factor for morbidity and mortality. Anaemia is mostly the result of an inadequate erythropoiesis due to iron deficiency, lack of vitamin B12 or folate, and bone marrow diseases. Among the elderly, renal disease and chronic inflammation account for approximately one-third of all anaemia incidences. The aim of this study is to provide detailed data about the prevalence of preoperative deficiencies in iron, vitamin B12 and/or folate and the presence of underlying renal or chronic diseases in patients undergoing major surgery.
Detailed description
Preoperative anaemia is common in surgery, with a prevalence between 10 and 50 %, and is an independent risk factor for morbidity and mortality. Due to the potential risk of additional blood loss, anaemia represents a serious disease condition within the surgical field. Especially patients undergoing major elective surgery are at risk of substantial blood loss. Anaemia is mostly the result of an inadequate erythropoiesis due to iron deficiency, lack of vitamin B12 or folate, and bone marrow diseases. Among the elderly, renal disease and chronic inflammation account for approximately one-third of all anaemia incidences. The aim of this study is to provide detailed data about the prevalence of preoperative deficiencies in iron, vitamin B12 and/or folate and the presence of underlying renal or chronic diseases in patients undergoing major surgery. Results will facilitate design of supplementation strategies to improve haemoglobin level before surgery.
Interventions
None listed
Sponsors
Medical University of Vienna
University Hospital, Angers
Medical University of Graz
Hospital del Mar
Hospital Hietzing
University of Zurich
Goethe University
Auckland City Hospital
Johann Wolfgang Goethe University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * Written informed consent prior to study participating according to the national law requirements * Patients undergoing major surgery * Expected hospital stay with a minimum of 24 hours
Exclusion criteria
* Preoperative autologous blood donation * Patients with expected re-surgery within the planned 7-day recruitment period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of preoperative anaemia | prior surgery | Hemoglobin level |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of patient with revision | 90 day | Number of patients with Revision after surgery |
| Number of patients with mortality | 90 day | in-hospital |
| Number of patients with red blood cell transfusion | 30 day | Amount of transfused units per patient |
| Hospital and ICU length of stay | 30 days | Time from Admission till discharge |
| Incidence of hospital-acquired anaemia | 30 days | Hemoglobin level |
| Re-admission | up to 90 days after discharge | Re-admission rates up to 90 days |
Countries
Germany
Outcome results
None listed