Bipolar Disorder
Conditions
Keywords
Early Maladaptative Schemas, Cognition, Functioning
Brief summary
Early Maladaptive Schemas (EMS) are overactivated in euthymic bipolar disorders (BD) and are associated with poor psychosocial functioning and higher suicidality. The first objective of this study is to establish different clusters of EMS in euthymic bipolar disorders, compare these clusters according to the clinical characteristics of BD and neuropsychological performances and evaluate the temporal stability of these clusters at 12 and 24 months. The second objective of this study is to quantify the impact of EMS on functioning in euthymic BD, beyond the effect of cognition and residual depressive symptoms.
Detailed description
Early Maladaptive Schemas (EMS) are overactivated in euthymic bipolar disorders (BD) and are associated with poor psychosocial functioning and higher suicidality. However, few studies have explored EMS in bipolar disorders, despite EMS therapy is a promising tool for the psychotherapy of BD. This study will use the data collected at the Versailles Expert Center for Bipolar disorder, in the local FACE-BD registry. These data will be collected at the inclusion, 12 months and 24 months later. They included an extensive neuropsychological battery and an extensive evaluation of the clinical characteristics of bipolar disorder. EMS will be measured with the Young Schema Questionnaire Short Form 3. The first objective of this study is to establish different clusters of EMS in euthymic bipolar disorders, compare these clusters according to the clinical characteristics of BD and neuropsychological performances and evaluate the temporal stability of these clusters at 12 and 24 months. The second objective of this study is to quantify the impact of EMS on functioning in euthymic BD, beyond the effect of cognition and residual depressive symptoms.
Interventions
None listed
Sponsors
Fondation FondaMental
Versailles Saint-Quentin-en-Yvelines University
University of Bordeaux
Versailles Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
\- bipolar disorder according to DSM IV-R (structured clinical interview)
Exclusion criteria
* major depressive or manic or hypomanic during the evaluation * Montgomery Åsberg Depression Rating Scale ⩽10 * Young Mania Rating Scale ⩽12
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Early Maladaptative Schemas T0 | 18 measures by subject, assessed at inclusion | distance to the norm for the scores on each 18 early maladaptative schema measured with the Young Shema Questionnaire short form 3, no lower bound limit, no upper bound limit, a low score indicate a lower activation of the Early Maladaptative Schema |
| Early Maladaptative Schemas T12 | 18 measures by subject, assessed at 12 months | distance to the norm for the scores on each 18 early maladaptative schema measured with the Young Shema Questionnaire short form 3, no lower bound limit, no upper bound limit, a low score indicate a lower activation of the Early Maladaptative Schema |
| Early Maladaptative Schemas T24 | 18 measures by subject, assessed at inclusion 24 months | distance to the norm for the scores on each 18 early maladaptative schema measured with the Young Shema Questionnaire short form 3, no lower bound limit, no upper bound limit, a low score indicate a lower activation of the Early Maladaptative Schema |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| functioning | one measure by subject, assessed 3 times (inclusion, 12 months and 24 months) | total score on the Functioning Assessment Short Test (lower bound 0 upper bound 72, lower scores indicates better functioning) |
| Hypomania | one measure by subject, assessed 3 times (inclusion, 12 months and 24 months) | total score on the Young Mania Rating Scale (lower bound 0 upper bound 12, lower scores indicate lower hypomania |
| Depression | one measure by subject, assessed 3 times (inclusion, 12 months and 24 months) | total score on the Montgomery Åsberg Depression Rating Scale (minimum 0 maximum 10) |
| Cognition | 5 measures by subject, assessed 2 times (at inclusion and 24 months) | distance to the norm for the scores for each the five cognitive dimension measured with the standardised neuropsychological battery, no lower bound limit, no upper bound limit, lower scores indicate poorer cognition |
Countries
France
Contacts
Primary ContactPaul ROUX, MD PhD
Outcome results
None listed