Diet Modification, Metabolic Syndrome, Shift-Work Related Sleep Disturbance, Work-Related Condition
Conditions
Keywords
Shift Work, Night Work, Rotating Shift Work, Metabolic Syndrome, Diet Therapy, Canola oil, Fatty Acids, Cardiometabolic parameters
Brief summary
Shift work is associated with a higher risk of the development of cardiometabolic syndrome (CMtS) than in people working only during the day. One of the factors predisposing to the development of the CMtS in shift workers is an inappropriate composition of their diet. It was observed that the shift workers diet is characterized by a higher intake of saturated fatty acids (SFA) and a lower consumption of unsaturated fatty acids. One potential way to reduce the risk of CMtS in this study group seems to be a modification of their everyday diet by excluding the products of animal origin (e.g. butter) with simultaneously including vegetable oils (i.e. canola oil). The aim of the study is to evaluate the effect of replacement in the everyday diet of saturated fats (butter) with unsaturated fats (canola oil-based spread and canola oil added to main meals) in centrally obese shift workers on changes in body weight and body composition parameters as well as on changes in CMtS markers.
Detailed description
The study was designed as a randomized clinical trial to investigate the effects of the dietary intervention with moderate in fat content (\ 35% energy as fat) for 12 weeks on the improvement of cardiometabolic risk factors in centrally obese shift workers. Forty centrally obese shift workers (waist circumference ≥94 cm) were randomized (1:1) to the experimental group (n = 20) or the control group (n = 20). Eligibility criteria included: aged between 30-60 years, working rotating shifts for at least 5 years and working night shifts minimum five times a month. Excluded criteria was described in the point Eligibility. Written informed consent was obtained from all of the participants, and the local ethic committee approved the study. The dietary intervention was mainly based on the simple rearrangement of shift workers' diets by replacing food items including SFA (e.g. butter) with those being sources of unsaturated fatty acids (UFA), mainly canola oil (given to the diet as spread or this oil was added separately to main meals)
Interventions
BEHAVIORALIntervention group
Isocaloric diet including \ 50g canola oil
BEHAVIORALControl group
ESC/EAS Guidelines for the management of dyslipidemias
Sponsors
Poznan University of Life Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
30 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* centrally obese (≥ 94cm) male * aged between 30-60 years, * working rotating shifts for at least 5 years and working night shifts minimum five times a month,
Exclusion criteria
* diabetes, familial hypercholesterolemia, thyroid and parathyroid diseases, non-specific intestinal diseases, celiac disease, phenylketonuria, * taking medication for lowering blood lipids such as statins, * weight loss therapy for 3 months before the intervention, * allergies and intolerances * consuming high-proof alcoholic beverages (\>2 portions/week)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Waist circumference (WC) | Baseline, 4, 8 and 12 week | Changes in WC within groups and between groups |
| HDL-cholesterol (HDL-C) | Baseline, 12 week | Changes in HDL-C within groups and between groups |
| LDL-cholesterol (LDL-C) | Baseline, 12 week | Changes in LDL-C within groups and between groups |
| Triglycerides (TG) | Baseline, 12 week | Changes in TG within groups and between groups |
| Glucose (GLU) | Baseline, 12 week | Changes in GLU within groups and between groups |
| Blood pressure (BP) | Baseline, 12 week | Changes in BP within groups and between groups |
| Body weight (BW) | Baseline, 4, 8 and 12 week | Changes in BW within groups and between groups |
| Fat mass (FM) | Baseline, 4, 8 and 12 week | Changes in FM within groups and between groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Melatonin (MEL) | Baseline, 12 week | Changes in MEL within groups and between groups |
| High-sensitivity C-reactive Protein (hs-CRP) | Baseline, 12 week | Changes in hs-CRP within groups and between groups |
| Dietary intake | Baseline, 4, 8, 12 week | Changes in dietary intake within groups and between groups |
| Fatty acids (FA) erythrocyte membranes concentration | Baseline, 12 week | Changes in FA within groups and between groups |
| Cardiotrophin-1 (CT-1) | Baseline, 12 week | Changes in CT-1 within groups and between groups |
| Lipase (LPS) | Baseline, 12 week | Changes in LPS within groups and between groups |
| Cholinesterase (CHE) | Baseline, 12 week | Changes in CHE within groups and between groups respectively |
| Alanine transaminase (ALT) | Baseline, 12 week | Changes in ALT within groups and between groups |
| Aspartate transaminase (AST) | Baseline, 12 week | Changes in AST within groups and between groups |
| Insulin (INS) | Baseline, 12 week | Changes in INS within groups and between groups |
| Gamma-glutamyltransferase (GGTP) | Baseline, 12 week | Changes in GGTP within groups and between groups |
Countries
Poland
Contacts
Primary ContactAgnieszka Kuleta-Koberska, MSc
Backup ContactJoanna Bajerska, Prof.
Outcome results
None listed