Cancer Colon
Conditions
Keywords
cancer, colon, tumor, colic
Brief summary
Developement of a clinical and biological database in colon cancer and colic tumors in order to better understand tumor invasion and metastatic scattering processes. The investigators hope that a better understanding of tumoral invasion process will lead to the discovery of new biomarkers and new drugs.
Detailed description
As the second leading cause of cancer-related death in France, colorectal cancer is a major public health problem. Each year, 37 000 cases are newly diagnosed in France and 17 000 patients die of the disease. Colorectal cancer is due to molecular and genetic damages involved in all tumorigenesis steps, transition from healthy tissue to adenoma and finally to invasive carcinoma stage. The investigators hope that a to better understand tumor invasion and metastatic scattering processes will allow therapeutic innovation and the emergence of new biomarkers. However, the study of early tumorigenesis phases as well as advanced stages of the disease is currently limited due to a lack of tissue samples. In this context, the Montpellier Cancer Institute (ICM) decided to initiate a biological collection dedicated to the tissular and blood samples of patients with colorectal cancer.
Interventions
OTHERBiological collection
The biological collection will also include samples of blood samples collected before or after surgery but also samples frozen and/or paraffin-embedded tissue sections.
Sponsors
Institut du Cancer de Montpellier - Val d'Aurelle
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patient undergoing colon cancer surgery (stage I, II, III and IV) 2. Patient operated for liver or lung or peritoneal carcinomatosis metastases originating from colon cancer 3. Patient operated for pre-neoplastic lesion (adenomatous polyp /villous adenoma polyp), 4. Patient with familial polyposis eligible for colectomy 5. Age \> 18 years 6. Signed informed consent
Exclusion criteria
1. Patient not affiliated to Social Protection system 2. Patient unable to understand or comply with study instructions or requirements for psychological, family, social or geographical reasons 3. Patient under guardianship 4. Minor patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of clinical risk factors for colorectal cancer | Until the study completion : 6 years |
| Number of biological risk factors for colorectal cancer | Until the study completion : 6 years |
Countries
France
Contacts
Primary ContactAurore MOUSSION
Outcome results
None listed