Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Cross-sectional Study.

Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Multiple Center, Cross-sectional Study.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03976739

Enrollment

1162

Registered

2019-06-06

Start date

2019-06-17

Completion date

2019-12-31

Last updated

2020-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bile Reflux Gastritis, Gastric Cancer, Helicobacter Pylori Infection, Intestinal Metaplasia, Precancerous Lesions

Keywords

gastric cancer; helicobacter pylori; precancerous lesion; bile reflux

Brief summary

To explore the effects of bile reflux on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.

Detailed description

This study was a multicenter cross-sectional study. Patients were consecutively enrolled and divided into gastric cancer group, gastric precancerous lesions group, and chronic gastritis group, according to histopathological results. The bile reflux detection rate and Helicobacter pylori infection status were recorded for each group.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

1. Age 18 to 75 years old, gender is not limited; 2. patients with upper abdominal pain, abdominal distension, belching, anorexia, early satiety, hiccup, acid reflux, upper abdomen burning sensation and other upper gastrointestinal symptoms; 3. Voluntary acceptance of Hp testing; 4. Voluntary acceptance of the endoscopy and pathological biopsy.

Exclusion criteria

1. had undergone upper gastrointestinal surgery; 2. Previous diagnosis of esophageal cancer; 3. Previous diagnosis of gastric cancer; 4. Previous diagnosis of MALT lymphoma; 5. pregnant and lactating women; 6. Those with mental disorders; 7. Refusal to sign the informed consent form.

Design outcomes

Primary

Measure	Time frame	Description
corelation between the bile reflux and gastric mucosa diseases	up to 6 months	we evaluate the corelation between the bile reflux and gastric mucosa diseases according to the histopathological results and the scales the patients finished

Secondary

Measure	Time frame	Description
the risk factors of primary bile reflux gastritis	up to 6 months	we evaluate the the risk factors of primary bile reflux gastritis according to the scales and endoscopical results

Countries

China

Outcome results