Alopecia Areata, Atopic Dermatitis, Psoriasis, Vitiligo
Conditions
Keywords
Skin inflammation, Cytokines
Brief summary
It is a study of translational research with mechanistically objectives and including biological samples of patients with chronic inflammatory disorders
Detailed description
This study was a single-center prospective study to collect blood and skin tissue at the time of consultation with a patient with non-segmental vitiligo, psoriasis, atopic dermatitis or alopecia areata, in order to better understand and compare blood and skin immune response in chronic inflammatory skin disorders: psoriasis, alopecia areata, atopic dermatitis and vitiligo.
Interventions
BIOLOGICALBlood samples
Blood samples: serum and PBMC
BIOLOGICALSkin biopsies
These superficial skin biopsies under local anesthesia in skin areas with the exception of the face and folds.
Sponsors
University Hospital, Bordeaux
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 18 to 75 years; * Patients with non-segmental vitiligo; * Patients with plaque psoriasis; * Patients with atopic dermatitis; * Patients with alopecia areata sclerosis; * written consent, free, informed and signed by the patient and the investigator (before any examination required by the study); * Subject affiliated or beneficiary of a social security system.
Exclusion criteria
* Patients with segmental vitiligo * Patients under local treatment (topical corticosteroid-Calcineurin inhibitor) for less than two weeks. * Patients on therapy, systemic treatments: acitretin, methotrexate, cyclosporine, Apremilast, infliximab, adalimumab, etanercept, ustekinumab, secukinumab, ixekizumab, dupilumab) for less than 4 weeks. * Pregnant or breastfeeding women * Patient (e) under guardianship * Patient (e) Non-affiliated (e) a social protection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Description of the phenotype and function of blood and skin T-cell in chronic inflammatory skin disorders: psoriasis, vitiligo, atopic dermatitis, alopecia areata | Day 1 | Description of the phenotypic analysis of cutaneous T-cell and blood of vitiligo patients evaluated by flow cytometry |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORJulien SENESCHAL, MD, PhD
University Hospital, Bordeaux
Outcome results
None listed