Streptococcus Infection
Conditions
Brief summary
The aim of the study is to evaluate streptococcal carriage by swab, pharyngeal, anal and perineal in patients with DHBN-FN, in the entourage living under the same roof as well as patients with erysipelas The main hypothesis is the major role of chronic porting of patients and entourage in DHBN-FN to SBH. Indeed, the chronic pharyngeal / anal / perineal carriage could be a gateway following a transient bacteremia for a DHBN-FN. The transmission of germs from the surrounding to the patient plays a major role: At the gateway level in the case of exogenous DHBN-FN At the origin of chronic carriage in the case of endogenous DHBN-FN Transmission of germs from the patient to the surrounding area also plays an important role in increasing the risk of invasive SBH infections in the surrounding area.
Interventions
OTHERDHBN-FN arm
DHBN-FN will be evaluated by pharyngeal swab, anal and perineal. If the family accepts, the carriage of streptococcus in persons living under the same roof as patients with DHBN-FN will be evaluated by pharyngeal, anal and perineal swab in consultation. These swabs will be made within 10 days of diagnosis of DHBN-FN of the index
OTHERControl arm (Erysipelas)
The carriage of streptococcus in patients with erysipelas will be evaluated by pharyngeal, anal and perineal swab on day 0 (admission).
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patient: * Major patient hospitalized for a DHBN-FN or erysipelas (clinical diagnosis determined at the entrance). * Signed informed consent. Case contact * person of major age living under the same roof as a patient who has had a DHBN-FN. * Signed informed consent
Exclusion criteria
* Patient: * Minor patient * Immunosuppressed patient: active hematology, poorly controlled HIV, neutropenia (PNN \<1000 / mm3). * Patient under guardianship or curatorship * Patient deprived of liberty by judicial or administrative decision * Patient not affiliated to a social security scheme and not a beneficiary of such a scheme Case contact * Minor person * Person under tutorship or curatorship * Person deprived of liberty by judicial or administrative decision * Person not affiliated with a social security
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of beta-hemolytic streptococcus in patients with DHBN-FN | Day 0 | Evaluation of streptococcal carriage by swab, pharyngeal, anal and perineal in patients hospitalized for a DHBN-FN . Swabs made by the dermatologist. The detection of beta-hemolytic streptococcus will be made by culture |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of SBH carriage at the time of diagnosis | Day 0, Day 10 | — |
| Sites of SBH carriage at the time of diagnosis | Day 0, Day 10 | — |
| Rate of beta-hemolytic streptococcus in patients with erysipelas | Day 0 | The carriage of streptococcus in patients with erysipelas will be evaluated by pharyngeal, anal and perineal swab on day 0. |
| Rate of beta-hemolytic streptococcus in patients living under the same roof as patients with DHBN-FN | Up to 10 Days | The carriage of streptococcus in persons living under the same roof as patients with DHBN-FN will be evaluated by pharyngeal, anal and perineal swab in consultation. These swabs will be made within 10 days of diagnosis of DHBN-FN of the index. |
| Main factors of streptococcal virulence | Day 0, Day 10 | Analyze the main factors of streptococcal virulence by Streptococcal genome sequencing |
Countries
France
Contacts
Primary ContactOlivier CHOSIDOW, Professor
Backup ContactCamille HUA, Doctor
Outcome results
None listed