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Using Digital Media Advertising to Reduce the Duration of Untreated Psychosis

Using Digital Media Advertising to Reduce the Duration of Untreated Psychosis

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03975400
Enrollment
698
Registered
2019-06-05
Start date
2020-04-22
Completion date
2023-05-31
Last updated
2023-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

First Episode Psychosis, Schizophrenia

Brief summary

There is compelling evidence that longer duration of untreated psychosis independently predicts negative outcomes. The proposal aims to explore whether targeted and proactive online outreach through search engine advertisements, coupled with engaging, informative, and interactive online resources, can effectively reduce the duration of untreated psychosis and facilitate earlier treatment initiation in New York State. Results from this initiative will be critical to informing the subsequent design and conduct of larger, focused, and proactive digital media campaigns targeting patient with First Episode Psychosis and their caregivers online, intended to accelerate linkage to care and reduce the duration of untreated psychosis throughout the U.S.

Detailed description

Approximately 100,000 individuals in the Unites States experience a first episode of psychosis (FEP) each year. Psychotic symptoms typically emerge during formative years of adolescence and young adult development and interfere with the establishment of healthy educational, vocational, and social foundations. Despite the severity of symptoms and significant decline in functioning, the time between symptom onset and receiving appropriate care in the U.S. is alarmingly lengthy. Longer Duration of Untreated Psychosis (DUP) has been shown to independently predict negative outcomes, including poorer response to treatment, worse global, vocational, social, and cognitive functioning, greater risk of relapse, higher symptom severity, and poorer quality of life. Prior successful DUP reduction initiatives have utilized various marketing strategies to educate the community about early intervention services, however these strategies are expensive, inefficient, and outdated. Targeted online outreach, supported by technological innovation, offers the prospect of proactively reaching individuals earlier in the course of illness development, as well as individuals who might not otherwise come into contact with traditional referral sources. In response to this challenge, Northwell Health's early psychosis research team is collaborating with Strong365, a nonprofit initiative dedicated to raising early psychosis intervention awareness, to develop and test a proactive and targeted comprehensive digital media marketing campaign designed to facilitate help-seeking and encourage treatment initiation in prospective patients with FEP and their caregivers. Investigators will take advantage of search engine advertisements, which allow advertisers (researchers) to select keywords/phrases and create linked ads appearing as a strategically placed search result. Dedicated ads will appear in response to online search queries conducted by prospective patients and their caregivers throughout New York State (NYS) that align with the campaign's pre-selected keywords/phrases. Individuals who click on the ads will be immediately directed to a landing page/website, and offered a variety of innovative and interactive online engagement tools intended to instantly connect users with specialty care staff and to facilitate earlier treatment initiation. Campaign referrals will be centralized and individuals with FEP will be enrolled into OnTrackNY (OTNY), a network of 21 dedicated early psychosis intervention programs throughout NYS. The campaign will target individuals as well as their caregivers, searching for psychosis-related terms or information online. Investigators will measure the DUP of individuals enrolled into OTNY before and after campaign activation and track the impact of the campaign on the number of FEP referrals and number of patients admitted to OTNY in NYS. Furthermore, investigators aim to identify the campaign target audience most effective at promoting treatment initiation as well as the online tools and resources most effective at encouraging treatment initiation for individuals with FEP. Investigators will additionally explore the online trajectories to care of individuals with FEP engaging with the campaign.

Interventions

BEHAVIORALsearch engine advertisement campaign

This proposal aims to explore whether targeted and proactive online outreach through search engine advertisements, coupled with engaging, informative, and interactive online resources, can effectively reduce the duration of untreated psychosis and facilitate earlier treatment initiation in New York State.

Sponsors

National Institute of Mental Health (NIMH)
CollaboratorNIH
Northwell Health
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
SCREENING
Masking
NONE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

All individuals searching online for information related to mental health

Exclusion criteria

none

Design outcomes

Primary

MeasureTime frameDescription
Reducing the Duration of Untreated Psychosis2 yearsEvaluate the effectiveness of a search engine ad campaign on reducing the duration of untreated psychosis (DUP) by directly comparing DUP pre-campaign to DUP during the campaign.

Secondary

MeasureTime frameDescription
Rates of Referrals2 yearsEvaluate the effectiveness of a search engine ad campaign on rates of referrals by directly comparing referrals pre-campaign to referrals during the campaign.

Countries

United States

Participant flow

Pre-assignment details

A stepped-wedge cluster randomization design was implemented. OTNY sites were grouped into 6 clusters/regions based on geolocation and the total number of referrals received at each clinic. The six clusters/regions were; 1) Bronx, 2) Manhattan, 3) Queens, 4) Brooklyn, 5) Hudson River/Central NY, 6) Staten Island/Long-Island/Western NY. There was a total of four 6-month time periods, including the baseline period where all 6 clusters receive the control treatment.

Participants by arm

ArmCount
Pre-Campaign
Investigators will measure the duration of untreated psychosis and rates of referrals to OnTrackNY programs throughout New York States prior to campaign initiation.
356
Active Campaign
Investigators will measure the duration of untreated psychosis and rates of referrals to OnTrackNY programs throughout New York States during the active campaign initiation. Search engine advertisement campaign: This proposal aims to explore whether targeted and proactive online outreach through search engine advertisements, coupled with engaging, informative, and interactive online resources, can effectively reduce the duration of untreated psychosis and facilitate earlier treatment initiation in New York State.
342
Total698

Baseline characteristics

CharacteristicActive CampaignTotalPre-Campaign
Age, Continuous21.26 years
STANDARD_DEVIATION 0.21
21.17 years
STANDARD_DEVIATION 0.92
21.03 years
STANDARD_DEVIATION 0.13
Ethnicity (NIH/OMB)
Hispanic or Latino
57 Participants137 Participants80 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
227 Participants465 Participants238 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
58 Participants96 Participants38 Participants
Race (NIH/OMB)
American Indian or Alaska Native
1 Participants1 Participants0 Participants
Race (NIH/OMB)
Asian
34 Participants68 Participants34 Participants
Race (NIH/OMB)
Black or African American
139 Participants290 Participants151 Participants
Race (NIH/OMB)
More than one race
5 Participants9 Participants4 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
1 Participants3 Participants2 Participants
Race (NIH/OMB)
Unknown or Not Reported
51 Participants92 Participants41 Participants
Race (NIH/OMB)
White
111 Participants235 Participants124 Participants
Sex: Female, Male
Female
105 Participants212 Participants107 Participants
Sex: Female, Male
Male
237 Participants486 Participants249 Participants

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
deaths
Total, all-cause mortality
0 / 3560 / 342
other
Total, other adverse events
0 / 3560 / 342
serious
Total, serious adverse events
0 / 3560 / 342

Outcome results

Primary

Reducing the Duration of Untreated Psychosis

Evaluate the effectiveness of a search engine ad campaign on reducing the duration of untreated psychosis (DUP) by directly comparing DUP pre-campaign to DUP during the campaign.

Time frame: 2 years

ArmMeasureValue (LEAST_SQUARES_MEAN)Dispersion
Pre-CampaignReducing the Duration of Untreated Psychosis5.32 DaysStandard Error 0.06
Active CampaignReducing the Duration of Untreated Psychosis5.38 DaysStandard Error 0.09
Secondary

Rates of Referrals

Evaluate the effectiveness of a search engine ad campaign on rates of referrals by directly comparing referrals pre-campaign to referrals during the campaign.

Time frame: 2 years

ArmMeasureValue (MEAN)Dispersion
Pre-CampaignRates of Referrals86.29 number of new referralsStandard Deviation 26.1
Active CampaignRates of Referrals32.10 number of new referralsStandard Deviation 5.38

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026