Healthy, Traumatic Brain Injury
Conditions
Brief summary
Traumatic brain injury (TBI) is a health issue impacting athletes and no clinical treatment protocol, other than rest, is yet established. The efficacy of a treatment protocol relies on objective, physiological measures of brain function and ultimately a quantification of injury severity. The present study aims to assess neurophysiological markers of auditory and visual measures of brain function using the NeuroCatch Platform and eye-tracking technology, respectively. The current gold standard of TBI evaluation, including cognitive and balance assessments, will also be captured.
Interventions
DEVICENeuroCatch Platform (NCP)
The NCP plays a proprietary 6-minute auditory stimulus sequence of tones and words that elicit involuntary evoked responses in the brain. Tone stimuli elicit N100 and P300 responses, and spoken word pairs elicit N400 responses. The NCP proprietary software identifies the latency and amplitude (timing and size) of three selected ERPs. Latency and amplitude values are reported as empirical (measured) values.
Sponsors
HealthTech Connex Inc.
Frederick Carrick, PhD, FACCN
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
14 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* Any sex, 14-25 years old inclusively * Attending the Creative Artists Agency LLC (CAA) hockey camp in July 2019 * Able to understand the informed consent/assent form, study procedures and willing to participate in study NeuroCatch Platform-Specific Inclusion Criteria * Able to remain seated and focused for 6 minutes * Normal hearing capabilities
Exclusion criteria
• Unable to provide informed consent NeuroCatch Platform-Specific
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ERP response size | 1 week | amplitude in microvolts |
| ERP response timing | 1 week | latency in milliseconds |
| Eye-tracking: target accuracy | 1 week | distance in millimeters for each eye |
| Eye-tracking: speed | 1 week | degrees per second |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive tests | 1 year | Cognitive assessments will be captured using Cambridge Brain Sciences battery of neuropsychological tests (composite score) and Highmark Interactive's EQ app |
| Balance | 1 week | Balance measured in seconds as captured by Highmark Interactive's EQ app |
Other
| Measure | Time frame | Description |
|---|---|---|
| Trends between outcome measures and demographics will be explored | 1 year | Demographics include age, concussion history, and handedness |
Countries
United States
Outcome results
None listed