Hepatocellular Carcinoma, Hypoproteinemia
Conditions
Brief summary
The rate of liver cirrhosis is about 40% to 75% among patients with hepatocellular carcinoma (HCC). Therefore, many patients with HCC were with low serum albumin before and after (especially) hepatic resection. Serum albumin level has been routinely used in clinical practice as a surrogate marker to evaluate nutritional status and liver function. Serum albumin concentration is used as an independent mortality risk predictor in a broad range of clinical and research settings. However, the role of albumin infusion in patients with hepatocellular carcinoma (HCC) after resection is unknown. The present study aimed to investigate the safety and clinical necessity of albumin infusion for HCC patients after hepatic resection.
Interventions
DRUGAlbumin infusion
Albumin infusion (20 g, ivgtt, qd) will be performed to patients with HCC after resection in 24 h for three days.
Sponsors
Guangxi Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index \>18.5; * Patients with primary hepatocellular carcinoma without any treatments for tumors before resection; * Hepatocellular carcinoma should be confirmed by histopathology; * With preserved liver function (Child-Pugh score ≤7) before resection * ECOG performance score 0 or 1; * Preoperative serum albumin \>35g/L; * The level of postoperative serum albumin is between 25-30g/L in the first day after resection.
Exclusion criteria
* Patients used albumin before liver resection (\<1 months); * Plasma was used during or after liver resection; * Surgery involving the extrahepatic bile duct or gastrointestinal tract.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum total bilirubin level | Change from Baseline total bilirubin at the fifth and seventh days after resection | Recovery of liver function between the two groups |
| Serum albumin level | Change from Baseline serum albumin at the fifth and seventh days after resection | Recovery of liver function between the two groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Abdominal girth | Change from Baseline abdominal girth at the fifth and seventh days after resection | Drainage liquid and abdominal girth between the two groups were compared |
| Rate of postoperative complications | The first months after resection | The rate of postoperative complications between the two groups were compared |
Countries
China
Contacts
Primary ContactJian-Hong Zhong, PdD
Backup ContactBang-De Xiang, PdD
Outcome results
None listed