Dental Caries, Periodontal Diseases
Conditions
Keywords
Xylitol, Saliva, Bacteria, Dental Plaque, Antimicrobial effect, Chewing gum
Brief summary
a double-blind cross-over in vivo study was performed to measure the salivary concentration of Xylitol released from the two chewing gums containing different amount of the polyol. The study had a cross-over design: the first half of the sample used the chewing-gum with Xylitol as the only sweeteners (64.5% of chewing-gum weight) and the other half use the chewing-gum with Xylitol among the sweeteners (22% of chewing-gum weight), after a 7-days wash-out period, the two sub-groups inverted the chewing gums. Subjects were instructed to consume the products as they normally would be consumed.
Detailed description
x
Interventions
DIETARY_SUPPLEMENT100% Xylitol Gum
Subjects were instructed to consume the gums as they normally would be consumed.
DIETARY_SUPPLEMENT22% Xylitol Gum
Subjects were instructed to consume the gums as they normally would be consumed.
Sponsors
University of Milan
Università degli Studi di Sassari
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
a double-blind cross-over in vivo study was performed to measure the salivary concentration of Xylitol released from the two chewing gums containing different amount of the polyol. The study had a cross-over design: the first half of the sample used the chewing-gum with Xylitol as the only sweeteners (64.5% of chewing-gum weight) and the other half use the chewing-gum with Xylitol among the sweeteners (22% of chewing-gum weight), after a 7-days wash-out period, the two sub-groups inverted the chewing gums. Subjects were instructed to consume the products as they normally would be consumed.
Eligibility
Sex/Gender
ALL
Age
19 Years to 26 Years
Healthy volunteers
Yes
Inclusion criteria
* good general health, * the absence of diseases that can alter the saliva secretion rate * a stimulated saliva flow at least of 1 ml/min.
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Salivary concentration of Xylitol | 9 days | Xylitol concentration using spectrophotometer analysis was determined in saliva before, at 0.30, 1.00, 2.00, 5.00, 10.00 minutes using the chewing-gum, and after the gum discarded at 15.00, 20.00 and 25.00 minutes. |
Countries
Italy
Outcome results
None listed