Meta-analysis of Stannous Fluoride and the Effects on Gingival Health

A Review of Meta-Analyses on Bioavailable Stannous Fluoride Dentifrices: Effects on Gingival Health

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03970759

Enrollment

2890

Registered

2019-06-03

Start date

2018-01-08

Completion date

2018-11-30

Last updated

2019-06-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingivitis

Brief summary

The aim of this 18 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices when used up to 3 months on gingivitis relative to a positive or negative control dentifrice.

Interventions

DRUGStannous Fluoride Dentifrice

Experimental stannous fluoride (0.454%) dentifrice

DRUGPositive control dentifrice

Positive control dentifrice containing (0.3%) triclosan.

DRUGNegative control dentifrice

Negative control dentifrice containing either sodium fluoride (0.243%) or sodium monofluorophosphate (0.76%)

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Subjects were excluded from this study for the following reasons; * pregnancy, * rampant caries, * severe periodontitis, * at discretionary of the Principal Investigator.

Design outcomes

Primary

Measure	Time frame	Description
Number of Bleeding Sites	Up to 12 Weeks	Change from baseline as measured on number of bleeding sites (gingival bleeding index or Loe Silness index).

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026