Lung Cancer Metastatic, Nodes, Lung
Conditions
Keywords
ultrasound, lymphadenopathy, lung cancer
Brief summary
This is a study of routine neck ultrasound performed by respiratory physicians in patients with mediastinal lymphadenopathy and suspected lung cancer
Detailed description
In the first phase of the study a respiratory physician was trained to perform neck ultrasound and needle sampling of enlarged cervical lymph nodes according to preset criteria. In the second phase patients with suspected lung cancer and enlarged mediastinal lymph nodes underwent routine neck ultrasound and enlarged cervical lymph nodes were sampled using fine needle and or core needle biopsy. The outcomes of interest in the study were the rate of malignant cervical lymphadenopathy defined as pathological evidence of cancer in neck lymph node samples consistent with a lung primary, adequacy of needle sampling, patient reported experience assessed by a visual analogue of discomfort associated with needle neck sampling and EBUS, and the proportion of patients that had nodal upstaging
Interventions
DIAGNOSTIC_TESTNeck ultrasound guide lymph node sampling
Neck ultrasound done first and lymph nodes larger than 5 mm that are technically feasible are sampled using fine needle aspiration and/or core needle biopsy
Sponsors
European Respiratory Society
University College Hospital Galway
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Inclusion criteria
* Suspected and later on confirmed lung cancer * Presence of at least one mediastinal lymph node measuring \> 10 mm in short diameter on computerised Tomography
Exclusion criteria
* Age \<18 * History any malignancy apart from non-melanomatous skin cancer * Inability to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Adequacy of lymph node sampling | 7 days | Presence of lymphocytes or malignant cells in biopsy samples |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of patients with malignant cervical lymphadenopathy | 7 days | Presence of malignant cells consistent with lung cancer in cervical lymph node samples |
| Proportion of patients with nodal status upstaged | 7 days | Defined as a change from cN2 to cN3 according to the 8th edition of the Tumour Node Metastasis TNM staging system |
Countries
Ireland
Outcome results
None listed