Acute Kidney Injury, Critical Illness
Conditions
Brief summary
This study evaluates a protocol for regional citrate anticoagulation in critically ill patients with acute kidney injury who are treated with continuous veno-venous haemofiltration in postdilution mode.
Detailed description
Acute kidney injury (AKI) requiring continuous renal replacement therapy (CCRT occurs in approx. 15 % of all intensive care patients. A sustained and prolonged filter running time is required to deliver an effective dialysis dose. This requires effective anticoagulation. Today, regional citrate anticoagulation (RCA) is preferred over systemic anticoagulation because of prolonged filter lifetimes and less adverse effects. We here study prospectively patients with AKI who are treated with continuous veno-venous haemofiltration using an RCA protocol. We will evaluate all parameters of CRRT including filter running times, delivered dialysis dose, causes for treatment interruption and control of pH and electrolytes.
Interventions
OTHERrenal replacement therapy as clinically indicated
Continuous renal replacement therapy
Sponsors
Diamed GmbH, Cologne, Germany
Heinrich-Heine University, Duesseldorf
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* acute kidney injury * critical illness and treatment at ICU
Exclusion criteria
* age \< 18 years * pregnancy or breast feeding * severe lactate acidosis ( \> 10 mmol/l) for longer than 6 hours and pH \< 7.2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Filter running time | 72 hours | Filterlifetime with regional citrate anticoagulation for haemofiltration |
Countries
Germany
Outcome results
None listed