Bromhidrosis
Conditions
Brief summary
The goal is to improve the underarm odor by changing the microbiome. The autochthonous bacterial community is replaced by a non-smelling microbiome, by daily application of bacteria in a spray.
Detailed description
Participants are recruited and selected based on their initial underarm odor and underarm microbiome. The participants use two sprays: one spray containing the bacteria, and the other nothing (placebo). Participants do not know which spray they have. They use one spray during one month, and meanwhile take samples of their underarm microbiome (for sequencing), volatome (for GC/MS analysis) and odor (for odor panel analysis). Samples are stored in the freezer and brought to the university after one month, when they receive the second spray. The bacterial spray contains bacteria that are correlated with good underarm odor.
Interventions
BIOLOGICALBacterial spray
Bacterial spray containing bacteria that do not cause underarm malodor
Sponsors
University Ghent
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Masking description
Double blind: participants nor outcome assessors, odor panel or care providers do not know which spray they use.
Intervention model description
two groups of 30 people, one month of bacterial spray use and the other month placebo.
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* above average underarm malodor * microbiome dominated with malodorous bacteria
Exclusion criteria
* not healthy * microbiome with too high levels of Staphylococcus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improved underarm odor | 1 month | Odor panel and GC/MS results provide insights on underarm odor development |
Countries
Belgium
Outcome results
None listed